Research ArticleTuberculosis

Metformin as adjunct antituberculosis therapy

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Science Translational Medicine  19 Nov 2014:
Vol. 6, Issue 263, pp. 263ra159
DOI: 10.1126/scitranslmed.3009885

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  • Tuberculostatic effect of metformin: Consider the elephant in the room

    Dear Editor,

    Singhal et al. demonstrate the inhibitory effect of metformin on growth of Mycobacterium tuberculosis (Mtb) in vitro and in vivo (1). We would like to draw attention to the potential role of the primary metabolite for which metformin is best known and prescribed, which is glucose itself. We believe metformin may affect growth of Mtb by restricting glucose availability.

    Glucose and infec...

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    Competing Interests: None declared.