The gut microbiota influences blood-brain barrier permeability in mice

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Science Translational Medicine  19 Nov 2014:
Vol. 6, Issue 263, pp. 263ra158
DOI: 10.1126/scitranslmed.3009759

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  • Meet at the blood-brain barrier - the unexpected encounter of sleep and gut microbiota

    In their recent paper, Braniste et al. (1) convincingly show that the presence of a microbial biota in the gut is necessary for the development and maintenance of a fully functional blood-brain barrier (BBB).

    It is remarkable that two recent reports have demonstrated that the BBB is also a target for regulation by sleep (2, 3). The sleep-dependent regulation of the BBB was deduced from sleep deprivation experimen...

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    Competing Interests: None declared.

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