19 November 2014
Vol 6, Issue 263
  • Contents

    • Editorial

    • Focus

      • The Blood-Brain Barrier’s Gut Check

        The gut microbiota may influence blood-brain barrier permeability during embryonic development, and this effect may be maintained into adulthood.

      • The Host Battles Drug-Resistant Tuberculosis

        The repurposed drug metformin reduces unproductive inflammation, refocuses host immune responses on the bacteria Mycobacterium tuberculosis, and thus may improve treatment outcomes for drug-resistant tuberculosis.

    • Research Articles

      • The gut microbiota influences blood-brain barrier permeability in mice

        The intestinal microbiota helps to maintain the integrity of the blood-brain barrier in fetal and adult mice.

      • Metformin as adjunct antituberculosis therapy

        Metformin can be repurposed as host-directed therapy for tuberculosis.

      • Rational design of small molecules as vaccine adjuvants

        Small-molecule immune potentiators can be engineered to be potent adjuvants with localized innate immune activation and short in vivo residence times.

      • A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

        Lipophilic bisphosphonates combined with rapamycin inhibit the growth of KRAS-mutant lung adenocarcinomas in mouse models.

    • Editors' Choice

      • Monkeying Around with LDL Receptor Levels

        A nuclear receptor signaling pathway’s effect on LDL receptor and cholesterol homeostasis is strikingly different between mice and monkeys.

      • Inhaling H(2)ope

        Inhaled hydrogen may improve survival and neurological outcomes following cardiac arrest.

      • Finding a Needle in a Myeloid Haystack

        Analysis of the myeloid compartment reveals a rare intratumoral dendritic cell population that stimulates cytotoxic T cells in multiple tumor types.

      • Heating Up: The Genetics of Febrile Seizures

        An array of rare and common genetic variants is associated with the fever-related seizures typically seen in children.

      • Shaping Up with the Gut Microbiota

        Host genetics influences the composition of the gut microbiota and reveals a family of bacteria that may prevent weight gain.

    • Podcast

About The Cover

Cover image expansion

ONLINE COVER A Gateway into the Brain. Brain tissue of a germ-free adult mouse (left) takes up more of the radioligand 11C-raclopride during PET imaging (yellow) compared to brain tissue of a pathogen-free mouse (middle) and a germ-free mouse colonized with a gut microbiota (right). Increased radioligand uptake by the germ-free mouse brain indicates a more permeable blood-brain barrier (BBB); the presence of a gut microbiota renders the BBB less permeable leading to reduced radioligand uptake (red) Braniste et al.. [CREDIT: MIKLÓS TÓTH, KAROLINSKA INSTITUTE]