Contents
Vol 6, Issue 263
Contents
Editorial
- Preterm Birth: Now the Leading Cause of Child Death Worldwide
Preterm birth is now the leading cause of death among young children worldwide, requiring a united effort to focus attention and investment on preventing prematurity.
Focus
- The Blood-Brain Barrier’s Gut Check
The gut microbiota may influence blood-brain barrier permeability during embryonic development, and this effect may be maintained into adulthood.
- The Host Battles Drug-Resistant Tuberculosis
The repurposed drug metformin reduces unproductive inflammation, refocuses host immune responses on the bacteria Mycobacterium tuberculosis, and thus may improve treatment outcomes for drug-resistant tuberculosis.
Research Articles
- The gut microbiota influences blood-brain barrier permeability in mice
The intestinal microbiota helps to maintain the integrity of the blood-brain barrier in fetal and adult mice.
- Metformin as adjunct antituberculosis therapy
Metformin can be repurposed as host-directed therapy for tuberculosis.
- Rational design of small molecules as vaccine adjuvants
Small-molecule immune potentiators can be engineered to be potent adjuvants with localized innate immune activation and short in vivo residence times.
- A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin
Lipophilic bisphosphonates combined with rapamycin inhibit the growth of KRAS-mutant lung adenocarcinomas in mouse models.
Editors' Choice
- Monkeying Around with LDL Receptor Levels
A nuclear receptor signaling pathway’s effect on LDL receptor and cholesterol homeostasis is strikingly different between mice and monkeys.
- Inhaling H(2)ope
Inhaled hydrogen may improve survival and neurological outcomes following cardiac arrest.
- Finding a Needle in a Myeloid Haystack
Analysis of the myeloid compartment reveals a rare intratumoral dendritic cell population that stimulates cytotoxic T cells in multiple tumor types.
- Heating Up: The Genetics of Febrile Seizures
An array of rare and common genetic variants is associated with the fever-related seizures typically seen in children.
- Shaping Up with the Gut Microbiota
Host genetics influences the composition of the gut microbiota and reveals a family of bacteria that may prevent weight gain.
Podcast
- Science Translational Medicine Podcast: 19 November 2014
Inder M. Verma talks about combining bisphosphonates and rapamycin to treat lung cancer.