Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

Prasad S. Adusumilli; Leonid Cherkassky; Jonathan Villena-Vargas; Christos Colovos; Elliot Servais; Jason Plotkin; David R. Jones; Michel Sadelain

doi:10.1126/scitranslmed.3010162

Research ArticleImmunotherapy

Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

Prasad S. Adusumilli¹,²,*,
Leonid Cherkassky¹,²,†,
Jonathan Villena-Vargas¹,²,†,
Christos Colovos¹,²,
Elliot Servais¹,²,
Jason Plotkin¹,
David R. Jones² and
Michel Sadelain¹,³,*

¹Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
²Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
³Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.

↵*Corresponding author. E-mail: adusumip{at}mskcc.org (P.S.A.); sadelaim{at}mskcc.org (M.S.)

↵† These authors contributed equally to this work and should be considered as second authors.

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Science Translational Medicine 05 Nov 2014:
Vol. 6, Issue 261, pp. 261ra151
DOI: 10.1126/scitranslmed.3010162

Prasad S. Adusumilli

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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For correspondence: adusumip@mskcc.org sadelaim@mskcc.org

Leonid Cherkassky

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Jonathan Villena-Vargas

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Christos Colovos

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Elliot Servais

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Jason Plotkin

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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David R. Jones

2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Michel Sadelain

1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.

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For correspondence: adusumip@mskcc.org sadelaim@mskcc.org

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Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

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