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Research ArticleImmunotherapy
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
- Prasad S. Adusumilli1,2,*,
- Leonid Cherkassky1,2,†,
- Jonathan Villena-Vargas1,2,†,
- Christos Colovos1,2,
- Elliot Servais1,2,
- Jason Plotkin1,
- David R. Jones2 and
- Michel Sadelain1,3,*
- 1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 3Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.
- ↵*Corresponding author. E-mail: adusumip{at}mskcc.org (P.S.A.); sadelaim{at}mskcc.org (M.S.)
-
↵† These authors contributed equally to this work and should be considered as second authors.
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Science Translational Medicine 05 Nov 2014:
Vol. 6, Issue 261, pp. 261ra151
DOI: 10.1126/scitranslmed.3010162
Vol. 6, Issue 261, pp. 261ra151
DOI: 10.1126/scitranslmed.3010162
Prasad S. Adusumilli
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Leonid Cherkassky
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jonathan Villena-Vargas
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Christos Colovos
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Elliot Servais
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jason Plotkin
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
David R. Jones
2Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Michel Sadelain
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
3Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.
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