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Public Biobanks: Calculation and Recovery of Costs

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Science Translational Medicine  05 Nov 2014:
Vol. 6, Issue 261, pp. 261fs45
DOI: 10.1126/scitranslmed.3010444
  • Table 1

    Tasks in biobanking.

    Block 1: Prebanking data
    Clinical data from general practice
    Questionnaire and survey
    Imaging
    Histopathology and cytology
    Serological tests
    Communication, information to donors, and informed consent
    Recording, processing, and data management (for example, LIMS)
    Storage and updating clinical data
    Data release
    Monitoring, audit
    Others
    Block 2: Collection of biological specimens
    Collection
    Accrual
    Processing of samples
    Storage
    Distribution and transport
    Dispatch management
    Quality control
    Monitoring/audit
    Others
    Block 3: Collection of data related to biological specimens
    Recording, storage, and data management
    Data analysis and linking with samples
    Quality control and computer-system engineering
    Dispatch management
    Monitoring, audit
    Others
    Block 4: Expertise
    Project management, advisory, and study design
    Recruitment
    Data generation
    Data analysis and statistics
    SOPs and support
    Processing
    Storage
    Quality management, certification and accreditation, audit
    Education and training
    Communication and public engagement
    Others
    Block 5: Administration and management
    Financial and administrative management
    Scientific management and strategy
    Loads and running charges
    Maintenance of equipment and consumables
    Internal R&D
    Investments
    Ethics and regulatory issues
    Partnership development, business development, contracts, networking
    Others

    Abbreviations: LIMS, Laboratory Information Management System; SOPs, Standard Operating Procedures.

    • Table 2

      Models for collaboration around biobanking costs.

      Model componentsModel 1: Full-cost modelModel 2: Partial-cost + fee modelModel 3: Marginal-cost model
      Items to which access is providedBiological samplesBiological samplesBiological samples
      Minimum data set defined by BBMRIData set defined by MTAAll data
      Medical and scientific expertise
      Material transfer agreementNo restriction on legal useRestricted to specific projectMTA is part of a collaboration agreement
      Intellectual propertyNot claimedUser has right of first refusal to IPIP shared as per collaboration agreement
      PublicationsBiobank acknowledgedBiobank acknowledged and described in Materials and MethodsCo-authorship + biobank acknowledged and described in Materials and Methods
      CostsFull cost of each samplePercent of full cost plus a contribution to the biobankConsumables and handling costs
      Example of prices / sample1000 to 2000 €200 to 500 €10 to 100 €

    Supplementary Materials

    • Supplementary Material for:

      Public Biobanks: Calculation and Recovery of Costs

      Bruno Clément,* Martin Yuille, Kurt Zaltoukal, Heinz-Erich Wichmann, Gabriele Anton, Barbara Parodi, Lukasz Kozera, Christian Bréchot, Paul Hofman, Georges Dagher, the EU-U.S. Expert Group on cost recovery in biobanks

      *Corresponding author. E-mail: bruno.clement@inserm.fr

      Published 5 November 2014, Sci. Transl. Med. 6, 261fs45 (2014)
      DOI: 10.1126/scitranslmed.3010444

      This PDF file includes:

      • Supplementary methods
      • Table S1. Expert group.
      • Table S2. Calculation grid for biobanks.

      [Download PDF]

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