Contents
Vol 6, Issue 261
Contents
Focus
- Public Biobanks: Calculation and Recovery of Costs
A group of experts aided development of a cost-related tool for biobank access prices and tested it in three partnership models.
Research Articles
- Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
Regional CAR T cell delivery provides superior protection compared to systemic administration.
- Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Single-cell pharmacokinetic analysis of a fluorescent eribulin derivative in vivo revealed drug resistance mediated by MDR1-driven efflux, which was overcome by a nanoencapsulated MDR1 inhibitor.
- A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
A prime-boost HCV vaccine strategy induces durable and broad T cell responses, characteristic of those associated with viral control.
- Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β-amyloid.
Editors' Choice
- Studying the “Soil” for Metastatic “Seeds”
A new bioengineered scaffold model can be used for studying tumor microenvironments.
- CAR T Cells Advance to the Next Level
CAR T cells redirected to CD19 in association with chimeric antigen receptors show potency in leukemia.
- Exploring the Link Between Traumatic Brain Injury and Dementia
In older people, experiencing an injury to the brain increases the risk of developing dementia.
- Lost Rhythms and the Failing Heart
Acute heart failure episodes place strain on heart myofibroblasts, leading to arrhythmias and sudden cardiac death.
Podcast
- Science Translational Medicine Podcast: 05 November 2014
Eleanor Barnes describes how a prime-boost vaccine strategy induces T cell responses that are important for HCV control.
Erratum
