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Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants

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Science Translational Medicine  29 Oct 2014:
Vol. 6, Issue 260, pp. 260ra150
DOI: 10.1126/scitranslmed.3009427

Article Information

vol. 6 no. 260 260ra150

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 29, 2014
  • Accepted for publication September 3, 2014
  • .

Author Information

  1. Rajesh A. Shenoi1,
  2. Manu Thomas Kalathottukaren1,
  3. Richard J. Travers2,
  4. Benjamin F. L. Lai1,
  5. A. Louise Creagh3,
  6. Dirk Lange4,
  7. Kai Yu1,
  8. Marie Weinhart1,
  9. Ben H. Chew4,
  10. Caigan Du4,
  11. Donald E. Brooks1,5,
  12. Cedric J. Carter1,
  13. James H. Morrissey2,
  14. Charles A. Haynes3 and
  15. Jayachandran N. Kizhakkedathu1,5,*
  1. 1Centre for Blood Research and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  2. 2Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  3. 3Michael Smith Laboratories, Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
  4. 4Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
  5. 5Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  1. *Corresponding author. E-mail: jay{at}pathology.ubc.ca

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