29 October 2014
Vol 6, Issue 260

About The Cover

Cover image expansion

ONLINE COVER Ultrasmall, Ultrabright. Nanoparticles have been heralded as the answer to challenges in drug delivery, imaging, and sensing, yet they have been limited in their translation to patients. Now, Phillips et al report the safety, pharmacokinetics, and biodistribution of ultrasmall (<10 nm) inorganic nanoparticles in five patients with metastatic melanoma. With a fluorescent core and radiolabeled peptide–polymer chains on the surface, the particles constitute a new class of hybrid optical-PET imaging agents that could soon be used to target and image patients' tumors noninvasively. A related Focus by Choyke puts this first-in-human study in perspective. [CREDIT: V. ALTOUNIAN, C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]