Contents
Vol 6, Issue 259
Contents
Focus
- Transforming Science, Service, and Society
Battling cancer in developing countries requires partnerships between cancer-care mentors from high-income countries and local community health workers.
- Bacterial Imaging Comes of Age
Enterobacteriaceae, a type of highly virulent Gram-negative bacteria, can be imaged in vivo via positron emission tomography with 18F-sorbitol.
Research Articles
- Targeting latent TGFβ release in muscular dystrophy
Blocking cleavage of latent TGFβ binding protein 4, a modifier of muscular dystrophy in humans and mice, inhibits release of latent TGFβ and decreases pathology in muscular dystrophy.
- TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis
TOPK inhibitor kills cancer cells by causing a cytokinesis defect and promotes tumor regression in mouse models.
- Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography
2-[18F]-Fluorodeoxysorbitol, a synthetic PET probe, can be used to rapidly, sensitively, and specifically image Gram-negative bacterial infections in animals.
Editors' Choice
- Short-Circuiting Mitochondria Leads to Improvement in Mouse Models of Diabetes
Diabetic symptoms can be improved in mice through mitochondrial decoupling with a currently approved anthelmintic drug.
- Elbow Grease
A biomimetic strategy to bind hyaluronic acid to joint and eye surfaces effectively increases lubrication.
- Treating Asthma: Divide and Conquer
Epithelial interleukin-25 expression segregates asthma subgroups that may respond to inhaled corticosteroid.
- Stem Cell Therapy for Diabetes Comes of Age
An optimized protocol enables the rapid generation of mature functional human β cells from pluripotent stem cells.
- Sequence-Specific Antibiotics
Modified CRISPR-Cas nucleases target pathogens or resistance genes for sequence-specific destruction.
