22 October 2014
Vol 6, Issue 259

About The Cover

Cover image expansion

ONLINE COVER Imaging Infection. Radiolabeled sugars can be used to image whole-body bacterial infection, reports a new study by Weinstein et al in this issue of Science Translational Medicine. In one example shown on the cover, mice with E. coli–infected hindlimbs were given either a commercially available imaging agent, 18F-fluorodeoxyglucose (animal on the left), or the author's experimental imaging agent, 18F-fluorodeoxysorbitol (animal on the right). Only 18F-labeled sorbitol was able to clearly distinguish infection in the animal's right thigh from sterile inflammation in the other using positron emission tomography. See the related Focus by Wang and Murthy on bacterial imaging. [CREDIT: A. ORDONEZ/JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE]