Contents

Contents

• Focus

  • Transforming Science, Service, and Society

    By C. Norman Coleman, Richard R. Love

    Science Translational Medicine22 Oct 2014 : 259fs42 Full AccessRestricted Access

    Battling cancer in developing countries requires partnerships between cancer-care mentors from high-income countries and local community health workers.

    • Abstract
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    • Supplementary Materials

  • Bacterial Imaging Comes of Age

    By Xiaojian Wang, Niren Murthy

    Science Translational Medicine22 Oct 2014 : 259fs43 Full AccessRestricted Access

    Enterobacteriaceae, a type of highly virulent Gram-negative bacteria, can be imaged in vivo via positron emission tomography with ¹⁸F-sorbitol.

    • Abstract
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• Research Articles

  • Targeting latent TGFβ release in muscular dystrophy

    By Ermelinda Ceco, Sasha Bogdanovich, Brandon Gardner, Tamari Miller, Adam DeJesus, Judy U. Earley, Michele Hadhazy, Lucas R. Smith, Elisabeth R. Barton, Jeffery D. Molkentin, Elizabeth M. McNally

    Science Translational Medicine22 Oct 2014 : 259ra144 Full AccessRestricted Access

    Blocking cleavage of latent TGFβ binding protein 4, a modifier of muscular dystrophy in humans and mice, inhibits release of latent TGFβ and decreases pathology in muscular dystrophy.

    • Editor's Summary
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    • Supplementary Materials

  • TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis

    By Yo Matsuo, Jae-Hyun Park, Takashi Miyamoto, Shinji Yamamoto, Shoji Hisada, Houda Alachkar, Yusuke Nakamura

    Science Translational Medicine22 Oct 2014 : 259ra145 Full AccessRestricted Access

    TOPK inhibitor kills cancer cells by causing a cytokinesis defect and promotes tumor regression in mouse models.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Imaging Enterobacteriaceae infection in vivo with ¹⁸F-fluorodeoxysorbitol positron emission tomography

    By Edward A. Weinstein, Alvaro A. Ordonez, Vincent P. DeMarco, Allison M. Murawski, Supriya Pokkali, Elizabeth M. MacDonald, Mariah Klunk, Ronnie C. Mease, Martin G. Pomper, Sanjay K. Jain

    Science Translational Medicine22 Oct 2014 : 259ra146 Full AccessRestricted Access

    2-[¹⁸F]-Fluorodeoxysorbitol, a synthetic PET probe, can be used to rapidly, sensitively, and specifically image Gram-negative bacterial infections in animals.

    • Editor's Summary
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    • Supplementary Materials

• Editors' Choice

  • Short-Circuiting Mitochondria Leads to Improvement in Mouse Models of Diabetes

    By Chester L. Drum

    Science Translational Medicine22 Oct 2014 : 259ec179 Full AccessRestricted Access

    Diabetic symptoms can be improved in mice through mitochondrial decoupling with a currently approved anthelmintic drug.

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  • Elbow Grease

    By Kara L. Spiller

    Science Translational Medicine22 Oct 2014 : 259ec180 Full AccessRestricted Access

    A biomimetic strategy to bind hyaluronic acid to joint and eye surfaces effectively increases lubrication.

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  • Treating Asthma: Divide and Conquer

    By Jie Sun

    Science Translational Medicine22 Oct 2014 : 259ec181 Full AccessRestricted Access

    Epithelial interleukin-25 expression segregates asthma subgroups that may respond to inhaled corticosteroid.

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  • Stem Cell Therapy for Diabetes Comes of Age

    By Paul J. Tesar

    Science Translational Medicine22 Oct 2014 : 259ec182 Full AccessRestricted Access

    An optimized protocol enables the rapid generation of mature functional human β cells from pluripotent stem cells.

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  • Sequence-Specific Antibiotics

    By Ephraim L. Tsalik

    Science Translational Medicine22 Oct 2014 : 259ec183 Full AccessRestricted Access

    Modified CRISPR-Cas nucleases target pathogens or resistance genes for sequence-specific destruction.

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