Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

S. Armando Villalta; Wendy Rosenthal; Leonel Martinez; Amanjot Kaur; Tim Sparwasser; James G. Tidball; Marta Margeta; Melissa J. Spencer; Jeffrey A. Bluestone

doi:10.1126/scitranslmed.3009925

Research ArticleMuscular Dystrophy

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

S. Armando Villalta¹,*,
Wendy Rosenthal¹,
Leonel Martinez²,
Amanjot Kaur¹,
Tim Sparwasser³,
James G. Tidball⁴,
Marta Margeta⁵,
Melissa J. Spencer² and
Jeffrey A. Bluestone¹,⁵,⁶

¹Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
²Department of Neurology and Center for Duchenne Muscular Dystrophy, University of California, Los Angeles, Los Angeles, CA 90095, USA.
³Institute for Infection Immunology, Twincore, Hannover 30625, Germany.
⁴Molecular, Cellular, and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁵Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
⁶Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

↵*Corresponding author. E-mail: avillalta{at}diabetes.ucsf.edu

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Science Translational Medicine 15 Oct 2014:
Vol. 6, Issue 258, pp. 258ra142
DOI: 10.1126/scitranslmed.3009925

S. Armando Villalta

1Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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For correspondence: avillalta@diabetes.ucsf.edu

Wendy Rosenthal

1Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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Leonel Martinez

2Department of Neurology and Center for Duchenne Muscular Dystrophy, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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Amanjot Kaur

1Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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Tim Sparwasser

3Institute for Infection Immunology, Twincore, Hannover 30625, Germany.

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James G. Tidball

4Molecular, Cellular, and Integrative Physiology Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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Marta Margeta

5Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

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Melissa J. Spencer

2Department of Neurology and Center for Duchenne Muscular Dystrophy, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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Jeffrey A. Bluestone

1Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

5Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

6Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

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