Contents
Vol 6, Issue 257
Contents
Editorial
- Five Years of Advancing Science, Improving Health
On its 5-year anniversary, Science Translational Medicine highlights its published research papers that have spurred encouraging translational progress.
Focus
- Type 2 Diabetes: Genotype-Based Therapy
Targeting a genetic variant with an antagonist may restore insulin secretion in a subgroup of type 2 diabetes patients.
Perspective
- Bionic Limbs: Clinical Reality and Academic Promises
Several new neuroprosthetic systems provide sensation via direct nerve stimulation, constituting an important step forward in achieving sensory-motor integration and embodiment of bionic limbs (Tan et al. and Ortiz-Catalan et al., this issue; Raspopovic et al., 5 Feb 2014 issue, 222ra19).
Research Articles
- A neural interface provides long-term stable natural touch perception
Electrical stimulation, using patterned intensity, applied through cuff-type peripheral nerve interfaces provided stable touch perceptions in the fingers, thumb, and hand of two subjects with upper limb loss for 16 to 24 months.
- Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist
The α2A-adrenergic receptor antagonist yohimbine improves insulin secretion in type 2 diabetics carrying the ADRA2A risk variant.
Reports
- An osseointegrated human-machine gateway for long-term sensory feedback and motor control of artificial limbs
An osseointegrated interface allowed long-term stable and bidirectional communication between robotic prostheses and implanted neuromuscular electrodes for intuitive control with sensory feedback in one patient.
- Noninvasive brain-computer interface enables communication after brainstem stroke
An individual “locked-in” by a brainstem stroke was able to communicate using noninvasive brain-computer interface technology.
Editors' Choice
- A Bug in the System for Artificial Sweeteners
Artificial sweeteners impair glucose tolerance in mice and humans by affecting the gut microbiome.
- Translational Tectonics for Stents
Measuring the pressure drop caused by a coronary artery occlusion enhances the therapeutic benefits of stent-based treatment of stable coronary heart disease.
- Protecting the Fortress: Preventing Metastasis by Neutralizing Niche Homing
Multiple myeloma metastasis can be prevented by neutralizing stromal-cell–derived factor 1 to inhibit tumor cell homing to the bone marrow.
- Shedding Light on the Genome’s Dark Matter
Recurrent mutations in noncoding DNA have been found in human tumors.
- A New Innate Cell on the Block
A new CD8α+ cell found in the intestine has innate-like functions and is important for promoting intestinal health.
