Research ArticleKidney Disease

A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation

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Science Translational Medicine  01 Oct 2014:
Vol. 6, Issue 256, pp. 256ra136
DOI: 10.1126/scitranslmed.3008538

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Focusing on Kidney Damage

Focal segmental glomerulosclerosis (FSGS) is a disease that damages podocytes, specialized cells that help the kidneys filter blood and produce urine. Over time, this condition leads to progressive deterioration of kidney function, and patients eventually require dialysis or kidney transplant. Unfortunately, the disease often recurs in the transplanted kidneys, causing them to fail as well. Now, Delville et al. present a panel of antibodies (Abs) that can be detected in the blood of patients whose FSGS is more likely to recur after transplant. The authors also highlight one specific Ab that appears to play the largest role in causing podocyte damage and demonstrate how its presence contributes to disease recurrence.