Research ArticleAsthma

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

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Science Translational Medicine  01 Oct 2014:
Vol. 6, Issue 256, pp. 256ra134
DOI: 10.1126/scitranslmed.3009124

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IL-25 Horns in on Asthma Attacks

The common cold isn’t so common in people with asthma. Rhinoviruses—the main causes of the common cold—can make asthma attacks worse. Now, Beale et al. report that one way this happens is because rhinoviruses can induce interleukin-25 (IL-25) in lung epithelial cells. They found that IL-25 is more highly expressed in people with asthma than in healthy controls. In a mouse model of allergic asthma, rhinovirus infection induced IL-25 production, and blocking the IL-25 receptor could reduce rhinovirus-induced symptom exacerbation. These data suggest that blocking IL-25 is a promising therapeutic strategy in asthmatics, something to consider as the cold season approaches.