01 October 2014
Vol 6, Issue 256

About The Cover

Cover image expansion

ONLINE COVER The Common Cold Heats Up Asthma Attacks. Shown is a rhinovirus, the predominant cause of the common cold. Partial antibodies (reds, oranges, and yellows) are bound to potential binding sites on the capsid (blues and greens). Asthmatics infected with rhinoviruses frequently have more severe asthma attacks. Now Beale et al. report that rhinoviruses induce the cytokine interleukin-25 (IL-25) in asthmatic lung cells and that IL-25 is a critical mediator for rhinovirus-induced asthma exacerbations. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]