Research ArticleCancer

Treatment of heterotopic ossification through remote ATP hydrolysis

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Science Translational Medicine  24 Sep 2014:
Vol. 6, Issue 255, pp. 255ra132
DOI: 10.1126/scitranslmed.3008810

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No Bones About It

Heterotopic ossification is a painful side effect that can complicate burns, trauma, and some types of surgery. In patients with this condition, small amounts of bone form in abnormal locations throughout the body, causing pain and complicating recovery. Now, Peterson et al. have developed a mouse model of heterotopic ossification, investigated the mechanism of this disorder, and then used their animal model to demonstrate a potential therapeutic intervention: topical application of apyrase. Although apyrase was only applied to the injury site, it decreased the abnormal formation of bone throughout the body. Other therapies, such as celecoxib and a drug called LDN-193189, were effective as well, suggesting the possibility of multiple therapeutic options for preventing heterotopic ossification in injured patients.

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