Research ArticleSurgery

Clinical recovery from surgery correlates with single-cell immune signatures

See allHide authors and affiliations

Science Translational Medicine  24 Sep 2014:
Vol. 6, Issue 255, pp. 255ra131
DOI: 10.1126/scitranslmed.3009701

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Signaling Surgical Recovery

The speed and ease of recovery after surgery differ for every patient, and determining the mechanisms that drive recovery could lead to patient-specific recovery protocols. Gaudilliere et al. used mass cytometry to characterize postsurgical immunological insult at a single-cell level and found a surgical immune signature that correlated with clinical recovery across patients. Specifically, cell signaling responses, but not cell frequency, were linked to recovery. Moreover, the correlated signaling responses occurred most notably in CD14+ monocytes, suggesting that these cells may play a predominant role in surgical recovery. The consistency of this signature across patients suggests a tightly regulated immune response to surgical trauma, which, if validated, may form the basis of a diagnostic guideline for personalized postsurgical care.

View Full Text