Contents
Vol 6, Issue 255
Contents
Focus
- Burned to the Bone
Heterotopic ossification—a complication of severe burns, head or blast injuries, and orthopaedic trauma—can result from altered adenosine metabolism in mesenchymal stem cells in response to elevated extracellular ATP (Peterson et al., this issue).
Commentary
- Genomic Complexity: A Call to Action
Because of their genomic simplicity relative to mature cancers, pre-malignant tissues might harbor therapeutic targets for drugs that destroy cancers before they appear.
Research Articles
- Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
The decrease of function in the ALDH2*2 genotype disrupts an important cardioprotective oxidative stress regulatory circuit, thus increasing cardiac cell death after ischemic insult.
- Clinical recovery from surgery correlates with single-cell immune signatures
Single-cell mass cytometry revealed immune correlates of patient-associated variability in surgical recovery.
- Treatment of heterotopic ossification through remote ATP hydrolysis
Heterotopic ossification induced by injuries and burns is mediated by signaling through the SMAD pathway and can be targeted with topical apyrase.
- Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury
Closed-loop neuromodulation of spinal sensorimotor circuits allows high-fidelity control over leg movements in paralyzed rats.
Editors' Choice
- Urothelial Carcinogenesis: A Tale of Two Cells
A study in a mouse model of chemical-induced bladder cancer shows different cells of origin for different histopathologiocal types of urothelial carcinoma.
- A Cancer Drug Promotes Hair Growth
Blockade of cytokine production with JAK-targeted drugs promotes hair growth in mice and humans with alopecia areata.
- Tackling the Persistent Effects of Concussion
Transcranial magnetic stimulation improved symptoms in subjects experiencing persistent negative effects after a concussion.
- Picturing Inflammation in Blood Vessels
Investigators have successfully imaged the dynamics of leukocyte infiltration into atherosclerotic plaques in humans.
Retraction