Contents

Contents

• Focus

  • Burned to the Bone

    By Jonathan A. Forsberg, Thomas A. Davis, Eric A. Elster, Jeffrey M. Gimble

    Science Translational Medicine24 Sep 2014 : 255fs37 Full AccessRestricted Access

    Heterotopic ossification—a complication of severe burns, head or blast injuries, and orthopaedic trauma—can result from altered adenosine metabolism in mesenchymal stem cells in response to elevated extracellular ATP (Peterson et al., this issue).

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• Commentary

  • Genomic Complexity: A Call to Action

    By William N. Hait, Arnold J. Levine

    Science Translational Medicine24 Sep 2014 : 255cm10 Full AccessRestricted Access

    Because of their genomic simplicity relative to mature cancers, pre-malignant tissues might harbor therapeutic targets for drugs that destroy cancers before they appear.

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• Research Articles

  • Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

    By Antje D. Ebert, Kazuki Kodo, Ping Liang, Haodi Wu, Bruno C. Huber, Johannes Riegler, Jared Churko, Jaecheol Lee, Patricia de Almeida, Feng Lan, Sebastian Diecke, Paul W. Burridge, Joseph D. Gold, Daria Mochly-Rosen, Joseph C. Wu

    Science Translational Medicine24 Sep 2014 : 255ra130 Full AccessRestricted Access

    The decrease of function in the ALDH2*2 genotype disrupts an important cardioprotective oxidative stress regulatory circuit, thus increasing cardiac cell death after ischemic insult.

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  • Clinical recovery from surgery correlates with single-cell immune signatures

    By Brice Gaudillière, Gabriela K. Fragiadakis, Robert V. Bruggner, Monica Nicolau, Rachel Finck, Martha Tingle, Julian Silva, Edward A. Ganio, Christine G. Yeh, William J. Maloney, James I. Huddleston, Stuart B. Goodman, Mark M. Davis, Sean C. Bendall, Wendy J. Fantl, Martin S. Angst, Garry P. Nolan

    Science Translational Medicine24 Sep 2014 : 255ra131 Full AccessRestricted Access

    Single-cell mass cytometry revealed immune correlates of patient-associated variability in surgical recovery.

    • Editor's Summary
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  • Treatment of heterotopic ossification through remote ATP hydrolysis

    By Jonathan R. Peterson, Sara De La Rosa, Oluwatobi Eboda, Katherine E. Cilwa, Shailesh Agarwal, Steven R. Buchman, Paul S. Cederna, Chuanwu Xi, Michael D. Morris, David N. Herndon, Wenzhong Xiao, Ronald G. Tompkins, Paul H. Krebsbach, Stewart C. Wang, Benjamin Levi

    Science Translational Medicine24 Sep 2014 : 255ra132 Full AccessRestricted Access

    Heterotopic ossification induced by injuries and burns is mediated by signaling through the SMAD pathway and can be targeted with topical apyrase.

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  • Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

    By Nikolaus Wenger, Eduardo Martin Moraud, Stanisa Raspopovic, Marco Bonizzato, Jack DiGiovanna, Pavel Musienko, Manfred Morari, Silvestro Micera, Grégoire Courtine

    Science Translational Medicine24 Sep 2014 : 255ra133 Full AccessRestricted Access

    Closed-loop neuromodulation of spinal sensorimotor circuits allows high-fidelity control over leg movements in paralyzed rats.

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• Editors' Choice

  • Urothelial Carcinogenesis: A Tale of Two Cells

    By Bishoy M. Faltas

    Science Translational Medicine24 Sep 2014 : 255ec163 Full AccessRestricted Access

    A study in a mouse model of chemical-induced bladder cancer shows different cells of origin for different histopathologiocal types of urothelial carcinoma.

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  • A Cancer Drug Promotes Hair Growth

    By Marcela V. Maus

    Science Translational Medicine24 Sep 2014 : 255ec164 Full AccessRestricted Access

    Blockade of cytokine production with JAK-targeted drugs promotes hair growth in mice and humans with alopecia areata.

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  • Tackling the Persistent Effects of Concussion

    By Daniel K. Nishijima

    Science Translational Medicine24 Sep 2014 : 255ec165 Full AccessRestricted Access

    Transcranial magnetic stimulation improved symptoms in subjects experiencing persistent negative effects after a concussion.

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  • Picturing Inflammation in Blood Vessels

    By Eric C. Stecker

    Science Translational Medicine24 Sep 2014 : 255ec166 Full AccessRestricted Access

    Investigators have successfully imaged the dynamics of leukocyte infiltration into atherosclerotic plaques in humans.

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• Retraction

  • Retraction of the Letter: “Comment on ‘CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy’ ”

    By Robbert van der Most, Martine Wettendorff, Bruce Innis, Emmanuel Hanon

    Science Translational Medicine24 Sep 2014 : 255rt2 Full AccessRestricted Access

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