Contents
Vol 6, Issue 252
Contents
Focus
- Traumatic Brain Injury: Lungs in a RAGE
Individuals who die of traumatic brain injury show damage to the lungs mediated by the HMGB1-RAGE axis, which renders the lungs suboptimal for transplantation (Weber et al.).
Commentary
- Breaking Down Translation Barriers: Investigator’s Perspective
Biomedical scientists can exploit initiatives from U.S. federal regulatory and funding agencies aimed at accelerating clinical translation.
Perspective
- Arterial Innervation in Development and Disease
Deciphering the mechanisms underlying sympathetic arterial innervation might produce new treatments for vascular diseases.
Research Articles
- Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
Breast-feeding and bottle-feeding promote different gut microbial communities, which are associated with development of different immune systems in rhesus macaque infants.
- A therapeutically targetable mechanism of BCR-ABL–independent imatinib resistance in chronic myeloid leukemia
A large-scale RNA interference screen reveals a new mechanism of imatinib resistance in chronic myeloid leukemia that can be therapeutically targeted.
- Prostate cancer cell–stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases
Dovitinib is therapeutically active in a subset of patients with prostate cancer bone metastases, partly due to blockade of FGFR-mediated stromal-epithelial interactions in the bone microenvironment.
- Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome
Patients with genetic disease of unknown causes can be rapidly diagnosed by bioinformatic analysis of disease-associated DNA sequences and phenotype.
- The HMGB1-RAGE axis mediates traumatic brain injury–induced pulmonary dysfunction in lung transplantation
Traumatic brain injury induces acute lung injury that negatively impacts the physiology of the donor lung before and after lung transplantation.
Editors' Choice
- Human Cells: Finally Open for Cancer Business
Insertional mutagenesis of normal human cells with a transposon-expressing lentivirus leads to better cancer cell models.
- Old-Age Interfer(on)ing
Age-dependent cognitive decline is linked to an increased interferon response in brain–circulatory system interface.
- Window of Opportunity
Carbon nanotubes along with new medical imaging tools provide a clear view of blood flow in the brain.
- The Microbial Origins of Obesity
Disrupting the early-life gut microbiota induces lasting and transmissible metabolic changes.
- Immune System Crashes After a Brake Failure
Hyperactivation in the PI3K-triggered pathways can cause human primary immunodeficiencies.
