Research ArticleTuberculosis

IL-32 is a molecular marker of a host defense network in human tuberculosis

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Science Translational Medicine  20 Aug 2014:
Vol. 6, Issue 250, pp. 250ra114
DOI: 10.1126/scitranslmed.3009546

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Interleukin-32 (IL-32) could be a correlate of protection against tuberculosis. Montoya et al. report that IL-32 is a potential candidate marker of host defense against tuberculosis. Mycobacterium tuberculosis causes a sometimes deadly infection that nonetheless only develops to disease in about 10% of individuals. The authors performed gene expression profiles of human macrophages and found an association between IL-32 and the vitamin D antimicrobial pathway. Moreover, analysis of five different clinical data sets suggested that IL-32 can serve as a molecular marker of latent tuberculosis and may be activated in response to signaling by IL-15. These data suggest that IL-32 may not only serve as a putative correlate of protection but also contribute directly to host response to tuberculosis.