Contents
Vol 6, Issue 250
Contents
Focus
- Bench-to-Bench Bottlenecks in Translation
Transfers of biopharmaceutical inventions between firms resets and falsely shortens calculated translation times.
Research Articles
- Proteasome inhibitors increase missense mutated dysferlin in patients with muscular dystrophy
Proteasome inhibitors increase missense mutated dysferlin expression in skeletal muscle and monocytes in patients with muscular dystrophy.
- Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
Macrophage progenitors are an effective and long-lasting therapy of hereditary pulmonary alveolar proteinosis.
- IL-32 is a molecular marker of a host defense network in human tuberculosis
IL-32 links the microbicidal peptide pathway with resistance to disease progression in clinical tuberculosis.
- Denervation suppresses gastric tumorigenesis
Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans.
- Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA
Lipid nanoparticle delivery of anti-MARV nucleoprotein–targeting small interfering RNA can treat Marburg virus in nonhuman primates after symptom onset.
Editors' Choice
- Harnessing the Crowd for Neurology Research
Smartphone games can enable rapid collection of large amounts of neurological data from large populations.
- AHR: A Temple of Tolerance to Toxemia
Signaling via the aryl hydrocarbon receptor minimizes the detrimental effects of infection without compromising the immune response to invading organisms.
- Lung Inflammation Clocks In and Out
The actions of glucocorticoids are under the control of the local pulmonary clock.
- Toxic Proteins on the Move
The neurodegenerative protein huntingtin may spread throughout the brain from cell to cell, illuminating new therapeutic considerations.
- Modulating Intracerebral Hemorrhage
An oral drug that blocks brain inflammation reduced edema in patients with intracranial hemorrhage.
Podcast
- Science Translational Medicine Podcast: 20 August 2014
Timothy C. Wang talks about the role of nerves in the growth of gastric cancer.