Contents

Contents

• Focus

  • Bench-to-Bench Bottlenecks in Translation

    By Matthew J. Higgins, Jerry Thursby, Marie Thursby

    Science Translational Medicine20 Aug 2014 : 250fs32 Full AccessRestricted Access

    Transfers of biopharmaceutical inventions between firms resets and falsely shortens calculated translation times.

    • Abstract
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    • Supplementary Materials

• Research Articles

  • Proteasome inhibitors increase missense mutated dysferlin in patients with muscular dystrophy

    By Bilal A. Azakir, Beat Erne, Sabrina Di Fulvio, Guido Stirnimann, Michael Sinnreich

    Science Translational Medicine20 Aug 2014 : 250ra112 Full AccessRestricted Access

    Proteasome inhibitors increase missense mutated dysferlin expression in skeletal muscle and monocytes in patients with muscular dystrophy.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis

    By Christine Happle, Nico Lachmann, Jelena Škuljec, Martin Wetzke, Mania Ackermann, Sebastian Brennig, Adele Mucci, Adan Chari Jirmo, Stephanie Groos, Anja Mirenska, Christina Hennig, Thomas Rodt, Jens P. Bankstahl, Nicolaus Schwerk, Thomas Moritz, Gesine Hansen

    Science Translational Medicine20 Aug 2014 : 250ra113 Full AccessRestricted Access

    Macrophage progenitors are an effective and long-lasting therapy of hereditary pulmonary alveolar proteinosis.

    • Editor's Summary
    • Abstract
    • Full Text
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    • Supplementary Materials

  • IL-32 is a molecular marker of a host defense network in human tuberculosis

    By Dennis Montoya, Megan S. Inkeles, Phillip T. Liu, Susan Realegeno, Rosane M. B. Teles, Poorva Vaidya, Marcos A. Munoz, Mirjam Schenk, William R. Swindell, Rene Chun, Kathryn Zavala, Martin Hewison, John S. Adams, Steve Horvath, Matteo Pellegrini, Barry R. Bloom, Robert L. Modlin

    Science Translational Medicine20 Aug 2014 : 250ra114 Full AccessRestricted Access

    IL-32 links the microbicidal peptide pathway with resistance to disease progression in clinical tuberculosis.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Denervation suppresses gastric tumorigenesis

    By Chun-Mei Zhao, Yoku Hayakawa, Yosuke Kodama, Sureshkumar Muthupalani, Christoph B. Westphalen, Gøran T. Andersen, Arnar Flatberg, Helene Johannessen, Richard A. Friedman, Bernhard W. Renz, Arne K. Sandvik, Vidar Beisvag, Hiroyuki Tomita, Akira Hara, Michael Quante, Zhishan Li, Michael D. Gershon, Kazuhiro Kaneko, James G. Fox, Timothy C. Wang, Duan Chen

    Science Translational Medicine20 Aug 2014 : 250ra115 Full AccessRestricted Access

    Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

    By Emily P. Thi, Chad E. Mire, Raul Ursic-Bedoya, Joan B. Geisbert, Amy C. H. Lee, Krystle N. Agans, Marjorie Robbins, Daniel J. Deer, Karla A. Fenton, Ian MacLachlan, Thomas W. Geisbert

    Science Translational Medicine20 Aug 2014 : 250ra116 Full AccessRestricted Access

    Lipid nanoparticle delivery of anti-MARV nucleoprotein–targeting small interfering RNA can treat Marburg virus in nonhuman primates after symptom onset.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

• Editors' Choice

  • Harnessing the Crowd for Neurology Research

    By Anshu Bhardwaj

    Science Translational Medicine20 Aug 2014 : 250ec141 Full AccessRestricted Access

    Smartphone games can enable rapid collection of large amounts of neurological data from large populations.

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  • AHR: A Temple of Tolerance to Toxemia

    By Vipul Chitalia

    Science Translational Medicine20 Aug 2014 : 250ec142 Full AccessRestricted Access

    Signaling via the aryl hydrocarbon receptor minimizes the detrimental effects of infection without compromising the immune response to invading organisms.

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  • Lung Inflammation Clocks In and Out

    By Charles S. Dela Cruz

    Science Translational Medicine20 Aug 2014 : 250ec143 Full AccessRestricted Access

    The actions of glucocorticoids are under the control of the local pulmonary clock.

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  • Toxic Proteins on the Move

    By Erik Musiek

    Science Translational Medicine20 Aug 2014 : 250ec144 Full AccessRestricted Access

    The neurodegenerative protein huntingtin may spread throughout the brain from cell to cell, illuminating new therapeutic considerations.

    • Full Text

  • Modulating Intracerebral Hemorrhage

    By Daniel K. Nishijima

    Science Translational Medicine20 Aug 2014 : 250ec145 Full AccessRestricted Access

    An oral drug that blocks brain inflammation reduced edema in patients with intracranial hemorrhage.

    • Full Text

• Podcast

  • Science Translational Medicine Podcast: 20 August 2014

    By Timothy C. Wang, Yevgeniya Nusinovich

    Science Translational Medicine20 Aug 2014 : 250pc4 Full AccessRestricted Access

    Timothy C. Wang talks about the role of nerves in the growth of gastric cancer.

    • Abstract