A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft

Thusitha Gajanayake; Radu Olariu; Franck M. Leclère; Ashish Dhayani; Zijiang Yang; Anjan K. Bongoni; Yara Banz; Mihai A. Constantinescu; Jeffrey M. Karp; Praveen Kumar Vemula; Robert Rieben; Esther Vögelin

doi:10.1126/scitranslmed.3008778

Research ArticleTransplantation

A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft

Thusitha Gajanayake¹,²,*,
Radu Olariu¹,²,*,
Franck M. Leclère¹,²,
Ashish Dhayani³,
Zijiang Yang⁴,
Anjan K. Bongoni²,⁵,
Yara Banz⁶,
Mihai A. Constantinescu¹,²,
Jeffrey M. Karp⁴,†,
Praveen Kumar Vemula³,†,
Robert Rieben²,† and
Esther Vögelin¹,²

¹Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.
²Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.
³Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences Campus, Bangalore 560 065, India.
⁴Division of Biomedical Engineering and Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Heath Sciences and Technology, and Harvard Stem Cell Institute, Boston, MA 02139, USA.
⁵Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3010 Bern, Switzerland.
⁶Institute of Pathology, University of Bern, CH-3010 Bern, Switzerland.

↵†Corresponding author. E-mail: robert.rieben{at}dkf.unibe.ch (R.R.); praveenv{at}instem.res.in (P.K.V.); jmkarp{at}partners.org (J.M.K.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 13 Aug 2014:
Vol. 6, Issue 249, pp. 249ra110
DOI: 10.1126/scitranslmed.3008778

Thusitha Gajanayake

1Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

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Radu Olariu

1Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

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Franck M. Leclère

1Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

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Ashish Dhayani

3Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences Campus, Bangalore 560 065, India.

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Zijiang Yang

4Division of Biomedical Engineering and Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Heath Sciences and Technology, and Harvard Stem Cell Institute, Boston, MA 02139, USA.

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Anjan K. Bongoni

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

5Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3010 Bern, Switzerland.

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Yara Banz

6Institute of Pathology, University of Bern, CH-3010 Bern, Switzerland.

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Mihai A. Constantinescu

1Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

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Jeffrey M. Karp

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For correspondence: robert.rieben@dkf.unibe.ch praveenv@instem.res.in jmkarp@partners.org

Praveen Kumar Vemula

3Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences Campus, Bangalore 560 065, India.

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For correspondence: robert.rieben@dkf.unibe.ch praveenv@instem.res.in jmkarp@partners.org

Robert Rieben

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

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For correspondence: robert.rieben@dkf.unibe.ch praveenv@instem.res.in jmkarp@partners.org

Esther Vögelin

1Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.

2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.

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A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft

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