Research ArticleTransplantation
A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft
- Thusitha Gajanayake1,2,*,
- Radu Olariu1,2,*,
- Franck M. Leclère1,2,
- Ashish Dhayani3,
- Zijiang Yang4,
- Anjan K. Bongoni2,5,
- Yara Banz6,
- Mihai A. Constantinescu1,2,
- Jeffrey M. Karp4,†,
- Praveen Kumar Vemula3,†,
- Robert Rieben2,† and
- Esther Vögelin1,2
- 1Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH-3010 Bern, Switzerland.
- 2Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland.
- 3Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences Campus, Bangalore 560 065, India.
- 4Division of Biomedical Engineering and Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Heath Sciences and Technology, and Harvard Stem Cell Institute, Boston, MA 02139, USA.
- 5Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3010 Bern, Switzerland.
- 6Institute of Pathology, University of Bern, CH-3010 Bern, Switzerland.
- ↵†Corresponding author. E-mail: robert.rieben{at}dkf.unibe.ch (R.R.); praveenv{at}instem.res.in (P.K.V.); jmkarp{at}partners.org (J.M.K.)
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Science Translational Medicine 13 Aug 2014:
Vol. 6, Issue 249, pp. 249ra110
DOI: 10.1126/scitranslmed.3008778
