Contents
Vol 6, Issue 249
Contents
Research Articles
- Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection
Human β-defensin 1 plays a dual role in defending male fertility by promoting both the motility of sperm and its bactericidal activity.
- Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis
Infusion of lymph node–derived fibroblastic reticular cells into septic mice increases survival at late time points after disease onset.
- A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft
Tacrolimus-encapsulated hydrogels improve long-term survival of a vascularized composite allograft.
- Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses
Clostridium novyi-NT targets aberrant tumor physiology and can produce a precise, robust, and reproducible antitumor response.
State of the Art Reviews
- Lost but making progress—Where will new analgesic drugs come from?
Understanding the long-term consequences of pain on brain circuits is critical to improving assessment of potential treatments for chronic pain in humans.
- Translational pain research: Lessons from genetics and genomics
Genetic and genomic approaches are poised to identify opportune targets for the development of new, more effective pain therapeutics.
Editors' Choice
- Lumpers and Splitters: A New Molecular Taxonomy for Cancer
Data analysis of 12 different cancer types yields a new molecular taxonomy for cancer.
- Hybrid CARs for Cancer?
NKT cells, redirected by a chimeric antigen receptor, are a promising newcomer to the immunotherapy field.
- Understanding the Genetic Risk of Sudden Cardiac Death
A disease mutation causes long QT syndrome and sudden cardiac death through a new genetic regulatory mechanism.
