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Research ArticleMultiple Sclerosis
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
- Joel N. H. Stern1,*,†,
- Gur Yaari2,3,*,
- Jason A. Vander Heiden4,*,
- George Church5,
- William F. Donahue6,
- Rogier Q. Hintzen7,
- Anita J. Huttner2,
- Jon D. Laman8,
- Rashed M. Nagra9,
- Alyssa Nylander1,
- David Pitt1,
- Sriram Ramanan1,
- Bilal A. Siddiqui1,
- Francois Vigneault5,6,
- Steven H. Kleinstein2,4,‡§,
- David A. Hafler1,10,‡§ and
- Kevin C. O’Connor1,‡§
- 1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
- 2Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.
- 3Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel.
- 4Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
- 5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
- 6AbVitro Incorporated, Boston, MA 02210, USA.
- 7Department of Neurology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
- 8Department of Immunology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
- 9Neurology Research, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA.
- 10Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
- ↵§Corresponding author. E-mail: steven.kleinstein{at}yale.edu (S.H.K.); david.hafler{at}yale.edu (D.A.H.); kevin.oconnor{at}yale.edu (K.C.O.)
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Science Translational Medicine 06 Aug 2014:
Vol. 6, Issue 248, pp. 248ra107
DOI: 10.1126/scitranslmed.3008879
Vol. 6, Issue 248, pp. 248ra107
DOI: 10.1126/scitranslmed.3008879
Joel N. H. Stern
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
Gur Yaari
2Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.
3Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel.
Jason A. Vander Heiden
4Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
George Church
5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
William F. Donahue
6AbVitro Incorporated, Boston, MA 02210, USA.
Rogier Q. Hintzen
7Department of Neurology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
Anita J. Huttner
2Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.
Jon D. Laman
8Department of Immunology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
Rashed M. Nagra
9Neurology Research, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA.
Alyssa Nylander
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
David Pitt
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
Sriram Ramanan
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
Bilal A. Siddiqui
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
Francois Vigneault
5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
6AbVitro Incorporated, Boston, MA 02210, USA.
Steven H. Kleinstein
2Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.
4Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
David A. Hafler
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
10Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
Kevin C. O’Connor
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
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