Research ArticleMultiple Sclerosis
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
- Joel N. H. Stern1,*,†,
- Gur Yaari2,3,*,
- Jason A. Vander Heiden4,*,
- George Church5,
- William F. Donahue6,
- Rogier Q. Hintzen7,
- Anita J. Huttner2,
- Jon D. Laman8,
- Rashed M. Nagra9,
- Alyssa Nylander1,
- David Pitt1,
- Sriram Ramanan1,
- Bilal A. Siddiqui1,
- Francois Vigneault5,6,
- Steven H. Kleinstein2,4,‡§,
- David A. Hafler1,10,ठand
- Kevin C. O’Connor1,‡§
- 1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
- 2Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.
- 3Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel.
- 4Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
- 5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
- 6AbVitro Incorporated, Boston, MA 02210, USA.
- 7Department of Neurology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
- 8Department of Immunology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
- 9Neurology Research, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA.
- 10Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
- ↵§Corresponding author. E-mail: steven.kleinstein{at}yale.edu (S.H.K.); david.hafler{at}yale.edu (D.A.H.); kevin.oconnor{at}yale.edu (K.C.O.)
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↵* These authors equally contributed to this work.
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↵† Present address: Department of Science Education, Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY 11530, USA.
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↵‡ Co-senior authors.
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Science Translational Medicine 06 Aug 2014:
Vol. 6, Issue 248, pp. 248ra107
DOI: 10.1126/scitranslmed.3008879
