Research ArticleMultiple Sclerosis

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

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Science Translational Medicine  06 Aug 2014:
Vol. 6, Issue 248, pp. 248ra107
DOI: 10.1126/scitranslmed.3008879

Article Information

vol. 6 no. 248 248ra107

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 21, 2014
  • Accepted for publication June 15, 2014
  • .

Author Information

  1. Joel N. H. Stern1,*,,
  2. Gur Yaari2,3,*,
  3. Jason A. Vander Heiden4,*,
  4. George Church5,
  5. William F. Donahue6,
  6. Rogier Q. Hintzen7,
  7. Anita J. Huttner2,
  8. Jon D. Laman8,
  9. Rashed M. Nagra9,
  10. Alyssa Nylander1,
  11. David Pitt1,
  12. Sriram Ramanan1,
  13. Bilal A. Siddiqui1,
  14. Francois Vigneault5,6,
  15. Steven H. Kleinstein2,4,§,
  16. David A. Hafler1,10,§ and
  17. Kevin C. O’Connor1,§
  1. 1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
  2. 2Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.
  3. 3Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel.
  4. 4Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
  5. 5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  6. 6AbVitro Incorporated, Boston, MA 02210, USA.
  7. 7Department of Neurology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
  8. 8Department of Immunology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
  9. 9Neurology Research, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA.
  10. 10Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.
  1. §Corresponding author. E-mail: steven.kleinstein{at}yale.edu (S.H.K.); david.hafler{at}yale.edu (D.A.H.); kevin.oconnor{at}yale.edu (K.C.O.)
    • * These authors equally contributed to this work.

    • Present address: Department of Science Education, Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY 11530, USA.

    • Co-senior authors.

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