Research ArticleCardiovascular Medicine

Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk

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Science Translational Medicine  06 Aug 2014:
Vol. 6, Issue 248, pp. 248ra105
DOI: 10.1126/scitranslmed.3009246

Article Information

vol. 6 no. 248 248ra105

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 8, 2014
  • Accepted for publication June 18, 2014
  • .

Author Information

  1. Douglas Moeckel1,
  2. Soon Soeg Jeong2,
  3. Xiaofeng Sun3,
  4. M. Johan Broekman4,5,
  5. Annie Nguyen1,
  6. Joan H. F. Drosopoulos4,5,
  7. Aaron J. Marcus4,5,
  8. Simon C. Robson3,
  9. Ridong Chen2,* and
  10. Dana Abendschein1,*
  1. 1Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  2. 2APT Therapeutics Inc., 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
  3. 3Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Thrombosis Research Laboratory, Research Service, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA.
  5. 5Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
  1. *Corresponding author. E-mail: rchen{at}apt-therapeutics.com (R.C.); dabendsc{at}DOM.wustl.edu (D.A.)

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