Research ArticleMalaria

New antigens for a multicomponent blood-stage malaria vaccine

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Science Translational Medicine  30 Jul 2014:
Vol. 6, Issue 247, pp. 247ra102
DOI: 10.1126/scitranslmed.3008705

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Combine and Conquer

Malaria vaccine development has been hampered by the inability to produce high-quality recombinant proteins for immunological studies. In a new study by Osier and colleagues, this constraint was overcome by systematically testing a library of biochemically active malaria parasite proteins in Kenyan children naturally exposed to malaria. The authors identified new proteins with superior or equivalent potential protective efficacy compared to established vaccine candidates. Moreover, cumulative responses to combinations of 5 of the top 10 ranked antigens correlated with 100% protection against malaria. These data suggest that there are potentially many more vaccine targets and that effective vaccination may be achieved through combinations of the best of these.

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