Research ArticleInfectious Disease

Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients

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Science Translational Medicine  23 Jul 2014:
Vol. 6, Issue 246, pp. 246ra98
DOI: 10.1126/scitranslmed.3008195

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Treating One Virus to Suppress Another

There is a complex interaction of biological effects when patients are infected with both HIV and the hepatitis C virus (HCV). In a new study of patients co-infected with HCV and HIV, Sherman et al. try and unravel some of these biological effects. They show that the initial response to effective HIV treatment results in a transient increase in HCV viral replication and evidence of liver injury. Over time, however, HIV suppression leads to reduced HCV replication. This process is highly modulated by responses of the interferon-responsive gene family. The findings suggest that HIV suppression with antiretroviral medications plays an important role in the management of those with HCV and HIV infection.

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