Research ArticleCystic Fibrosis

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

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Science Translational Medicine  23 Jul 2014:
Vol. 6, Issue 246, pp. 246ra97
DOI: 10.1126/scitranslmed.3008889

Article Information

vol. 6 no. 246 246ra97

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 24, 2014
  • Accepted for publication June 30, 2014
  • .

Author Information

  1. Guido Veit1,
  2. Radu G. Avramescu1,
  3. Doranda Perdomo1,
  4. Puay-Wah Phuan2,
  5. Miklos Bagdany1,
  6. Pirjo M. Apaja1,
  7. Florence Borot1,
  8. Daniel Szollosi3,4,
  9. Yu-Sheng Wu1,
  10. Walter E. Finkbeiner5,
  11. Tamas Hegedus3,4,
  12. Alan S. Verkman2 and
  13. Gergely L. Lukacs1,6,7,*
  1. 1Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada.
  2. 2Departments of Medicine and Physiology, University of California, San Francisco, San Francisco, CA 94143–0521, USA.
  3. 3MTA-SE Molecular Biophysics Research Group, Hungarian Academy of Sciences, 1444 Budapest, Hungary.
  4. 4Department of Biophysics and Radiation Biology, Semmelweis University, 1444 Budapest P.O. Box 263, Hungary.
  5. 5Department of Pathology, University of California, San Francisco, San Francisco, CA 94143–0511, USA.
  6. 6Department of Biochemistry, McGill University, Montréal, Quebec H3G 1Y6, Canada.
  7. 7Groupe de Recherche Axé sur la Structure des Protéines (GRASP), McGill University, Montréal, Quebec H3G 1Y6, Canada.
  1. *Corresponding author. E-mail: gergely.lukacs{at}mcgill.ca

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