Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

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  Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

  By Deborah M. Cholon, Nancy L. Quinney, M. Leslie Fulcher, Charles R. Esther, Jr., Jhuma Das, Nikolay V. Dokholyan, Scott H. Randell, Richard C. Boucher, Martina Gentzsch

  Science Translational Medicine23 Jul 2014 : 246ra96

  Ivacaftor, a CFTR potentiator drug used for cystic fibrosis, destabilizes rescued ΔF508 CFTR and interferes with the action of drugs that correct CFTR function.

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  Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

  By Deborah M. Cholon, Nancy L. Quinney, M. Leslie Fulcher, Charles R. Esther, Jr., Jhuma Das, Nikolay V. Dokholyan, Scott H. Randell, Richard C. Boucher, Martina Gentzsch

  Science Translational Medicine23 Jul 2014 : 246ra96

  Ivacaftor, a CFTR potentiator drug used for cystic fibrosis, destabilizes rescued ΔF508 CFTR and interferes with the action of drugs that correct CFTR function.

  • Supplementary Materials

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