Seeking Help: B Cells Adapting to Flu Variability

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Science Translational Medicine  23 Jul 2014:
Vol. 6, Issue 246, pp. 246ps8
DOI: 10.1126/scitranslmed.3008409

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The study of influenza vaccines has revealed potential interactions between preexisting immunological memory and antigenic context and/or adjuvantation. In the face of antigenic diversity, the process of generating B cell adaptability is driven by cross-reactive CD4 memory cells, such as T follicular helper cells from previous infections or vaccinations. Although such “helped” B cells are capable of adapting to variant antigens, lack of CD4 help could lead to a suboptimal antibody response. Collectively, this indicates an interplay between CD4 T cells, adjuvant, and B cell adaptability.

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