23 July 2014
Vol 6, Issue 246

About The Cover

Cover image expansion

ONLINE COVER Lupus the Wolf. The disease lupus is thought to be named for the Latin word for wolf. One suggestion as to etymology is that the disease was thought to devour the affected tissue or organ. Indeed, systemic lupus erythematosus (SLE) is a chronic autoimmune disease—in which the immune system attacks the body's own cells. SLE can damage any part of the body, and is incurable, but can be treated with immunosuppressants. Now, Wu et al. report that decreased expression of the B cell signaling inhibitor PTEN may contribute to lupus pathology and that targeting PTEN and it's regulator miR-7 may be therapeutic options for SLE. [CREDIT: TOM BRAKEFIELD/GETTY IMAGES]