Contents
Vol 6, Issue 246
Contents
Focus
- CFTR Potentiators: Not an Open and Shut Case
Positive and negative effects of drugs in cystic fibrosis raise questions about therapeutic development.
Perspective
- Seeking Help: B Cells Adapting to Flu Variability
CD4 T cell help, potentially driven by adjuvantation, increases B cell adaptability by driving the plasticity and evolution of B cells and, consequently, the antibody response to influenza antigens.
Research Articles
- Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis
Ivacaftor, a CFTR potentiator drug used for cystic fibrosis, destabilizes rescued ΔF508 CFTR and interferes with the action of drugs that correct CFTR function.
- Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression
Ivacaftor, a potentiator of ΔF508-CFTR channel function in cystic fibrosis, reduces the ability of corrector drugs to rescue the ΔF508-CFTR membrane trafficking defect.
- Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients
Treatment of HIV patients co-infected with hepatitis C virus (HCV) with HIV antiretroviral drug therapy reduces HCV replication.
- Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus
Decreased expression of PTEN regulated by miR-7 contributes to B cell hyperresponsiveness and disturbed B cell homeostasis in SLE.
Editors' Choice
- For IBD, Bugs and Genes Are the Name of the Game
Ileal microbe and tissue mRNA profiling may help provide better prognoses and therapies to treatment-naïve IBD patients.
- Swimming in Autism Mutations
Mutations in a gene that encodes a putative chromatin remodeler cause a distinct subtype of autism.
- Drink Your Juice! “Nanojuice” Shows Gut in Action
A new medical imaging reagent provides a noninvasive real-time view of the gut.
- All Systems Point to TREML4
RNA, DNA, and protein expression patterns were integrated to identify a genetic cause of coronary artery calcification.
