Research ArticleRadiation Toxicity

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

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Science Translational Medicine  16 Jul 2014:
Vol. 6, Issue 245, pp. 245ra93
DOI: 10.1126/scitranslmed.3008973

Article Information

vol. 6 no. 245 245ra93

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 6, 2013
  • Accepted for publication May 22, 2014
  • .

Author Information

  1. Vincent Favaudon1,2,*,
  2. Laura Caplier3,,
  3. Virginie Monceau4,5,,
  4. Frédéric Pouzoulet1,2,§,
  5. Mano Sayarath1,2,,
  6. Charles Fouillade1,2,
  7. Marie-France Poupon1,2,,
  8. Isabel Brito6,7,
  9. Philippe Hupé6,7,8,9,
  10. Jean Bourhis4,5,10,
  11. Janet Hall1,2,
  12. Jean-Jacques Fontaine3 and
  13. Marie-Catherine Vozenin4,5,10,11
  1. 1Institut Curie, Centre de Recherche, 91405 Orsay, France.
  2. 2INSERM U612, 91405 Orsay, France.
  3. 3Pathology Laboratory, Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est, 94704 Maisons Alfort, France.
  4. 4Université Paris-XI, 91405 Orsay, France.
  5. 5INSERM U1030, Institut Gustave-Roussy, 94805 Villejuif, France.
  6. 6Institut Curie, Centre de Recherche, 75248 Paris 05, France.
  7. 7INSERM U900, 75248 Paris 05, France.
  8. 8Mines ParisTech, 77305 Fontainebleau, France.
  9. 9CNRS, UMR144, 75248 Paris 05, France.
  10. 10Radio-Oncologie/Radiothérapie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
  11. 11INSERM U967, Commissariat à l’Énergie Atomique (CEA), Division des Sciences du Vivant (DSV), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), 92265 Fontenay aux Roses, France.
  1. *Corresponding author. E-mail: vincent.favaudon{at}curie.fr
  • Present address: BiodOxis, Parc Biocitech, 102 Avenue Gaston-Roussel, 93230 Romainville, France.

  • Present address: CNRS UMR 1166, La Pitié-Salpêtrière Hospital, 75013 Paris, France.

  • § Present address: Department of Translational Research, Institut Curie-Recherche, Building 101, Centre Universitaire, 91898 Orsay, France.

  • Present address: Institut Curie-Recherche, INSERM U1021/CNRS UMR 3347, 91405 Orsay, France.

  • Present address: XenTech, 4 rue Pierre-Fontaine, 91400 Evry, France.

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