16 July 2014
Vol 6, Issue 245

About The Cover

Cover image expansion

ONLINE COVER The Hardest Working Organ. The liver has a complex architecture with polarized epithelial cells called hepatocytes (beige) arranged into tracts called sinusoids. Hepatocytes along with other liver cell types including Kupffer cells (green) carry out more than 500 biological functions, including metabolic, synthetic, immune, and detoxification processes. The unique architecture of the liver presents special challenges for engineering liver tissue for transplantation, an urgent medical need given the insufficient number of donor organs available. In a State of the Art Review Bhatia and colleagues discuss these challenges and how advances in stem cell biology and engineering of tissues and devices are bringing the engineering of liver tissues for transplant closer to clinical reality. [CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]