Contents
Vol 6, Issue 245
Contents
Editorial
- More Health for the Money—Toward a More Rigorous Implementation Science
Rigorous implementation science can improve efforts to scale up effective health interventions.
Research Articles
- Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia
Preeclampsia is characterized by protein misfolding, aggregation, and amyloid-like plaque formation, suggesting that this pregnancy-related condition shares pathophysiologic features with protein conformational disorders.
- Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Pulsed, ultrahigh dose-rate irradiation is safer than standard radiotherapy for the treatment of lung cancer and selectively spares normal tissue.
- Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block
TBX18 gene therapy reprogrammed cardiomyocytes to become pacemaker cells in a pig model of heart block.
- An annexin A1–FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions
Annexin A1 secreted from drug-stimulated monocytes contributes to keratinocyte necroptosis in serious drug-related adverse events in skin.
State of the Art Review
- Cell and tissue engineering for liver disease
Advances in cell and tissue engineering are moving cell-based therapies for treating liver disease and liver failure closer to the clinic.
Editors' Choice
- Fishing for Drugs That Mitigate Metabolic Syndrome
A small-molecule agonist of the G protein–coupled receptor Gpr120 ameliorates metabolic syndrome in obese mice.
- RBCs: Repurposed and Refurbished
A new method of stably modifying red blood cells enhances their potential for diagnostic and therapeutic drug delivery applications.
- Using Mutant IDH1 to Arm the Immune System in Cancer
A new antitumor vaccine targets mutant IDH1.
- What’s Your Attitude?
Genetics experts weigh in on whether and how to return incidental findings from exome sequencing.
- An Unexpected Player in Diabetes
Heme oxygenase-1 is associated with insulin resistance in obese individuals, and excessive amounts in mouse liver exacerbate inflammation, leading to metabolic disease.
