09 July 2014
Vol 6, Issue 244
  • Contents

    • Editorial

      • BRAIN Initiative to Transform Human Imaging

        The BRAIN initiative’s call for invention of the next generation of human imaging systems will help discover answers to some of our most challenging health mysteries across all organ systems.

    • Research Articles

      • Cortical GABAergic excitation contributes to epileptic activities around human glioma

        Epileptic discharges in the neocortex surrounding human gliomas are initiated by GABAergic interneurons through alterations of chloride homeostasis in pyramidal cells.

      • Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

        Signatures from patients with both psoriasis and eczema contribute to understanding disease pathogenesis and diagnosis.

      • EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype

        A subtype of aggressive human muscle-invasive bladder cancer expresses basal epithelial markers and is sensitive to EGFR inhibition in preclinical models.

    • Reports

    • Editors' Choice

      • The Art of War on Viruses

        Computation-based protein design reveals a potent inhibitor of the Epstein-Barr viral protein that prevents apoptosis of the infected host cell.

      • Viewing T Cell Biology Through a Genomic Lens

        Deep sequencing of single T cells simultaneously identifies information about their antigen specificity, clonal ancestry, and function.

      • Shedding (UV) Light on Multiple Sclerosis

        Ultraviolet light therapy suppresses demyelination in a mouse model of multiple sclerosis and induces potentially protective immune responses in humans.

About The Cover

Cover image expansion

ONLINE COVER Revolutionizing Human Brain Imaging. During the Scientific Revolution, the Milky Way—on the cover showing the constellations Sagittarius and Scorpius—was thought to be a cloud of light-reflecting dust. Then Galileo used the newly invented telescope to show that this cloud was, in fact, made up of individual stars. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative similarly hopes to refine our view of the human brain by stimulating new imaging approaches. Of the six high-priority BRAIN initiatives outlined in June 2014, only one focuses on next-generation human brain imaging—an area that is of particular interest to the National Institute of Biomedical Imaging and Bioengineering (NIBIB). In this issue's Editorial by Pettigrew, director of the NIBIB, stresses the importance of pushing the boundaries of imaging science and opines on the impact that this unique imaging initiative will have on elucidating the great mysteries of the human brain. [CREDIT: B. TAFRESHI/SCIENCE SOURCE]