Contents
Vol 6, Issue 244
Contents
Editorial
- BRAIN Initiative to Transform Human Imaging
The BRAIN initiative’s call for invention of the next generation of human imaging systems will help discover answers to some of our most challenging health mysteries across all organ systems.
Research Articles
- Cortical GABAergic excitation contributes to epileptic activities around human glioma
Epileptic discharges in the neocortex surrounding human gliomas are initiated by GABAergic interneurons through alterations of chloride homeostasis in pyramidal cells.
- Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema
Signatures from patients with both psoriasis and eczema contribute to understanding disease pathogenesis and diagnosis.
- EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype
A subtype of aggressive human muscle-invasive bladder cancer expresses basal epithelial markers and is sensitive to EGFR inhibition in preclinical models.
Reports
- Plasmodium falciparum transmission stages accumulate in the human bone marrow
Sexual stages of the human malaria parasite Plasmodium falciparum use the hematopoietic system of the bone marrow as a developmental niche.
Editors' Choice
- Dissecting the Enigma of Mycobacterium tuberculosis Pathogenesis
pH-dependent adaptations and host carbon sources play crucial roles in Mycobacterium tuberculosis infection.
- α-Ketoglutarate—A New Currency of Longevity
A product of tricarboxylic acid metabolism, α-ketoglutarate prolongs life span.
- The Art of War on Viruses
Computation-based protein design reveals a potent inhibitor of the Epstein-Barr viral protein that prevents apoptosis of the infected host cell.
- Viewing T Cell Biology Through a Genomic Lens
Deep sequencing of single T cells simultaneously identifies information about their antigen specificity, clonal ancestry, and function.
- Shedding (UV) Light on Multiple Sclerosis
Ultraviolet light therapy suppresses demyelination in a mouse model of multiple sclerosis and induces potentially protective immune responses in humans.
