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Research ArticleHIV
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
- Amarendra Pegu1,
- Zhi-yong Yang1,
- Jeffrey C. Boyington1,
- Lan Wu1,
- Sung-Youl Ko1,
- Stephen D. Schmidt1,
- Krisha McKee1,
- Wing-Pui Kong1,
- Wei Shi1,
- Xuejun Chen1,
- John-Paul Todd1,
- Norman L. Letvin1,2,*,
- Jinghe Huang3,
- Martha C. Nason4,
- James A. Hoxie5,
- Peter D. Kwong1,
- Mark Connors3,
- Srinivas S. Rao1,
- John R. Mascola1,† and
- Gary J. Nabel1,†
- 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
- 2Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P. O. Box 15732, Boston, MA 02115, USA.
- 3HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
- 4Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA.
- 5Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵†Corresponding author. E-mail: jmascola{at}nih.gov (J.R.M.); gary.nabel{at}sanofi.com (G.J.N.)
-
↵* Deceased.
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Science Translational Medicine 02 Jul 2014:
Vol. 6, Issue 243, pp. 243ra88
DOI: 10.1126/scitranslmed.3008992
Vol. 6, Issue 243, pp. 243ra88
DOI: 10.1126/scitranslmed.3008992
Amarendra Pegu
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Zhi-yong Yang
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Jeffrey C. Boyington
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Lan Wu
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Sung-Youl Ko
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Stephen D. Schmidt
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Krisha McKee
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Wing-Pui Kong
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Wei Shi
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Xuejun Chen
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
John-Paul Todd
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Norman L. Letvin
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
2Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P. O. Box 15732, Boston, MA 02115, USA.
Jinghe Huang
3HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
Martha C. Nason
4Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA.
James A. Hoxie
4Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA.
Peter D. Kwong
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Mark Connors
3HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
Srinivas S. Rao
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
John R. Mascola
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
Gary J. Nabel
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
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