Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

Amarendra Pegu; Zhi-yong Yang; Jeffrey C. Boyington; Lan Wu; Sung-Youl Ko; Stephen D. Schmidt; Krisha McKee; Wing-Pui Kong; Wei Shi; Xuejun Chen; John-Paul Todd; Norman L. Letvin; Jinghe Huang; Martha C. Nason; James A. Hoxie; Peter D. Kwong; Mark Connors; Srinivas S. Rao; John R. Mascola; Gary J. Nabel

doi:10.1126/scitranslmed.3008992

Research ArticleHIV

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

Amarendra Pegu¹,
Zhi-yong Yang¹,
Jeffrey C. Boyington¹,
Lan Wu¹,
Sung-Youl Ko¹,
Stephen D. Schmidt¹,
Krisha McKee¹,
Wing-Pui Kong¹,
Wei Shi¹,
Xuejun Chen¹,
John-Paul Todd¹,
Norman L. Letvin¹,²,*,
Jinghe Huang³,
Martha C. Nason⁴,
James A. Hoxie⁵,
Peter D. Kwong¹,
Mark Connors³,
Srinivas S. Rao¹,
John R. Mascola¹,† and
Gary J. Nabel¹,†

¹Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.
²Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P. O. Box 15732, Boston, MA 02115, USA.
³HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
⁴Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA.
⁵Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

↵†Corresponding author. E-mail: jmascola{at}nih.gov (J.R.M.); gary.nabel{at}sanofi.com (G.J.N.)

↵* Deceased.

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Science Translational Medicine 02 Jul 2014:
Vol. 6, Issue 243, pp. 243ra88
DOI: 10.1126/scitranslmed.3008992

Amarendra Pegu

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Zhi-yong Yang

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Jeffrey C. Boyington

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Lan Wu

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Sung-Youl Ko

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Stephen D. Schmidt

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Krisha McKee

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Wing-Pui Kong

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Wei Shi

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Xuejun Chen

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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John-Paul Todd

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Norman L. Letvin

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

2Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P. O. Box 15732, Boston, MA 02115, USA.

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Jinghe Huang

3HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.

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Martha C. Nason

4Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA.

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James A. Hoxie

4Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA.

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Peter D. Kwong

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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Mark Connors

3HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.

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Srinivas S. Rao

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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John R. Mascola

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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For correspondence: jmascola@nih.gov gary.nabel@sanofi.com

Gary J. Nabel

1Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, MD 20892, USA.

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For correspondence: jmascola@nih.gov gary.nabel@sanofi.com

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Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

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