Research ArticleNeurodegenerative Disease

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Science Translational Medicine  02 Jul 2014:
Vol. 6, Issue 243, pp. 243ra86
DOI: 10.1126/scitranslmed.3009093

Article Information

vol. 6 no. 243 243ra86

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History: 
  • Received for publication March 20, 2014
  • Accepted for publication June 13, 2014
  • .

Author Information

  1. Gernot Kleinberger1,2,
  2. Yoshinori Yamanishi3,
  3. Marc Suárez-Calvet1,4,5,
  4. Eva Czirr6,7,
  5. Ebba Lohmann8,9,10,
  6. Elise Cuyvers11,12,
  7. Hanne Struyfs13,
  8. Nadine Pettkus1,
  9. Andrea Wenninger-Weinzierl14,
  10. Fargol Mazaheri14,
  11. Sabina Tahirovic14,
  12. Alberto Lleó4,5,
  13. Daniel Alcolea4,5,
  14. Juan Fortea4,5,
  15. Michael Willem1,
  16. Sven Lammich1,
  17. José L. Molinuevo15,
  18. Raquel Sánchez-Valle15,
  19. Anna Antonell15,
  20. Alfredo Ramirez16,17,
  21. Michael T. Heneka18,19,
  22. Kristel Sleegers11,12,
  23. Julie van der Zee11,12,
  24. Jean-Jacques Martin20,
  25. Sebastiaan Engelborghs13,21,
  26. Asli Demirtas-Tatlidede8,
  27. Henrik Zetterberg22,23,
  28. Christine Van Broeckhoven11,12,
  29. Hakan Gurvit8,
  30. Tony Wyss-Coray6,7,24,
  31. John Hardy23,
  32. Marco Colonna3 and
  33. Christian Haass1,2,14,*
  1. 1Adolf-Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, 80336 Munich, Germany.
  2. 2Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany.
  3. 3Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  4. 4Department of Neurology, Institut d’Investigacions Biomèdiques, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, 08025 Barcelona, Spain.
  5. 5Center for Networked Biomedical Research for Neurodegenerative Diseases, CIBERNED, 28031 Madrid, Spain.
  6. 6Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  7. 7Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
  8. 8Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
  9. 9Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.
  10. 10German Center for Neurodegenerative Diseases (DZNE), Tübingen, 72076 Tübingen, Germany.
  11. 11Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerp, Belgium.
  12. 12Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, 2610 Antwerp, Belgium.
  13. 13Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, 2610 Antwerp, Belgium.
  14. 14German Center for Neurodegenerative Diseases (DZNE), Munich, 80336 Munich, Germany.
  15. 15Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic i Universitari, 08036 Barcelona, Spain.
  16. 16Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
  17. 17Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
  18. 18Universitätsklinikum Bonn, Neurology, 53127 Bonn, Germany.
  19. 19German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
  20. 20Antwerp Biobank, Institute Born-Bunge, University of Antwerp, 2610 Antwerp, Belgium.
  21. 21Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, 2020 Antwerp, Belgium.
  22. 22Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.
  23. 23Reta Lila Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
  24. 24Neuroscience IDP Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
  1. *Corresponding author. E-mail: christian.haass{at}dzne.lmu.de

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