Research ArticleCancer

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

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Science Translational Medicine  25 Jun 2014:
Vol. 6, Issue 242, pp. 242ra84
DOI: 10.1126/scitranslmed.3008455

Article Information

vol. 6 no. 242 242ra84

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 3, 2014
  • Accepted for publication April 10, 2014
  • .

Author Information

  1. Lihong Xu1,
  2. Janine Stevens1,
  3. Mary Beth Hilton1,2,
  4. Steven Seaman1,
  5. Thomas P. Conrads3,*,
  6. Timothy D. Veenstra3,
  7. Daniel Logsdon2,
  8. Holly Morris4,
  9. Deborah A. Swing4,
  10. Nimit L. Patel5,
  11. Joseph Kalen5,
  12. Diana C. Haines6,
  13. Enrique Zudaire1 and
  14. Brad St. Croix1,
  1. 1Tumor Angiogenesis Section, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI) at Frederick, National Institutes of Health, Frederick, MD 21702, USA.
  2. 2Basic Research Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  3. 3Laboratory of Proteomics and Analytical Technologies, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  4. 4Transgenic Core Facility, MCGP, NCI, Frederick, MD 21702, USA.
  5. 5Small Animal Imaging Program/LASP, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  6. 6Pathology/Histotechnology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  1. Corresponding author. E-mail: stcroix{at}ncifcrf.gov
  • * Present address: Women’s Health Integrated Research Center (WHIRC) at Inova Health System, Annandale, VA 22003, USA.

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