1Department of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.
2Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
3The Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94110, USA.
4Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD 20878, USA.
5Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Cambridge CB21 6GH, UK.
6Laboratory of Structure and Function of Biological Membranes, University of Brussels, Brussels 1000, Belgium.
7Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
8Department of Surgery, University of California, San Francisco, San Francisco, CA 94110, USA.
9Department of Pulmonary Medicine, Jikei University, Tokyo 105 8461, Japan.
10Genetics, Development, and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94110, USA.
3The Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94110, USA.
3The Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94110, USA.
eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Servicebefore submitting your own eLetter.
By Shunsuke Minagawa, Jianlong Lou, Robert I. Seed, Anthony Cormier, Shenping Wu, Yifan Cheng, Lynne Murray, Ping Tsui, Jane Connor, Ronald Herbst, Cedric Govaerts, Tyren Barker, Stephanie Cambier, Haruhiko Yanagisawa, Amanda Goodsell, Mitsuo Hashimoto, Oliver J. Brand, Ran Cheng, Royce Ma, Kate J. McKnelly, Weihua Wen, Arthur Hill, David Jablons, Paul Wolters, Hideya Kitamura, Jun Araya, Andrea J. Barczak, David J. Erle, Louis F. Reichardt, James D. Marks, Jody L. Baron, Stephen L. Nishimura
Science Translational Medicine : 241ra79
Therapeutic targeting of an extended-closed conformation of the integrin αvβ8 inhibits TGF-β activation and ameliorates symptoms of experimental airway disease in mice.
By Shunsuke Minagawa, Jianlong Lou, Robert I. Seed, Anthony Cormier, Shenping Wu, Yifan Cheng, Lynne Murray, Ping Tsui, Jane Connor, Ronald Herbst, Cedric Govaerts, Tyren Barker, Stephanie Cambier, Haruhiko Yanagisawa, Amanda Goodsell, Mitsuo Hashimoto, Oliver J. Brand, Ran Cheng, Royce Ma, Kate J. McKnelly, Weihua Wen, Arthur Hill, David Jablons, Paul Wolters, Hideya Kitamura, Jun Araya, Andrea J. Barczak, David J. Erle, Louis F. Reichardt, James D. Marks, Jody L. Baron, Stephen L. Nishimura
Science Translational Medicine : 241ra79
Therapeutic targeting of an extended-closed conformation of the integrin αvβ8 inhibits TGF-β activation and ameliorates symptoms of experimental airway disease in mice.
