18 June 2014
Vol 6, Issue 241

About The Cover

Cover image expansion

ONLINE COVER Breathing Freely. Narrowing of the airways caused by scar tissue and inflammation induced by cigarette smoke, allergens, and other injurious agents results in the breathlessness experienced by patients with chronic obstructive pulmonary disease (COPD). A monoclonal antibody (orange) engineered to lock αvβ8 integrin (blue) into a closed position was able to prevent activation of TGF-β, a key mediator of lung inflammation and fibrosis. When administered to mice expressing human αvβ8, the antibody reduced airway inflammation and fibrosis in response to cigarette smoke or allergens, suggesting a potential new therapeutic strategy for treating COPD (Minagawa et al.). [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]