Contents
Vol 6, Issue 241
Contents
Editorial
- Chronic Diseases in HIV Survivors
Screening and intervention programs are needed in low- and middle-income countries to address noncommunicable diseases arising in HIV-infected survivors on antiretroviral drug therapy.
Commentary
- Parallel Discovery of Alzheimer’s Therapeutics
Government support for parallel development of AD therapeutics.
Research Articles
- Circulating Cell-Free DNA Enables Noninvasive Diagnosis of Heart Transplant Rejection
In a prospective cohort study of heart transplant recipients, sequencing-based quantification of donor-derived DNA in plasma of recipients noninvasively diagnosed transplant rejection.
- In Vivo–Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response
Antigen-specific regulatory T cells induced in vivo have therapeutic effects in mice with established autoimmune diseases.
- Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease
Therapeutic targeting of an extended-closed conformation of the integrin αvβ8 inhibits TGF-β activation and ameliorates symptoms of experimental airway disease in mice.
- IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells
GM-CSF–producing T helper cells in humans follow a distinct regulation program as compared to TH17 cells and are associated with multiple sclerosis.
Editors' Choice
- Taking Cancer Cells Out of Circulation
Circulating cancer cells produce patient-specific tumors in mice that predict response to chemotherapy.
- A Stroke of Genius
Amyloid-β–targeted nanoparticles allow early detection and treatment of stroke-inducing cerebrovascular inflammation.
- A Punch to the Gut: IL-9 Promotes Ulcerative Colitis
Interleukin-9 amplifies mucosal inflammation and disrupts intestinal barrier function in ulcerative colitis.
- Power of the Young—New Stem Cell Source for Treating Autoimmune Disease
Human pluripotent stem cell–derived mesenchymal stem cells are more effective than adult bone marrow–derived cells in a mouse model of multiple sclerosis.
