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Research ArticleIdiopathic Pulmonary Fibrosis
Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis
- Yang Zhou1,*,
- Hong Peng2,*,
- Huanxing Sun1,*,
- Xueyan Peng1,
- Chuyan Tang1,
- Ye Gan1,
- Xiaosong Chen1,
- Aditi Mathur1,
- Buqu Hu1,
- Martin D. Slade1,
- Ruth R. Montgomery3,
- Albert C. Shaw3,
- Robert J. Homer4,
- Eric S. White5,
- Chang-Min Lee1,
- Meagan W. Moore1,
- Mridu Gulati1,
- Chun Geun Lee1,
- Jack A. Elias6,† and
- Erica L. Herzog1,†
- 1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
- 2Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
- 3Program on Aging, Yale School of Medicine, New Haven, CT 06520, USA.
- 4Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
- 5Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
- 6Division of Biology and Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI 02912, USA.
- ↵†Corresponding author. E-mail: erica.herzog{at}yale.edu (E.L.H.); jack_elias{at}brown.edu (J.A.E.)
-
↵* These authors contributed equally to this work.
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Science Translational Medicine 11 Jun 2014:
Vol. 6, Issue 240, pp. 240ra76
DOI: 10.1126/scitranslmed.3007096
Vol. 6, Issue 240, pp. 240ra76
DOI: 10.1126/scitranslmed.3007096
Yang Zhou
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Hong Peng
2Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
Huanxing Sun
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Xueyan Peng
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Chuyan Tang
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Ye Gan
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Xiaosong Chen
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Aditi Mathur
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Buqu Hu
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Martin D. Slade
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Ruth R. Montgomery
3Program on Aging, Yale School of Medicine, New Haven, CT 06520, USA.
Albert C. Shaw
3Program on Aging, Yale School of Medicine, New Haven, CT 06520, USA.
Robert J. Homer
4Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Eric S. White
5Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Chang-Min Lee
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Meagan W. Moore
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Mridu Gulati
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Chun Geun Lee
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Jack A. Elias
6Division of Biology and Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI 02912, USA.
Erica L. Herzog
1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
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