Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

Yang Zhou; Hong Peng; Huanxing Sun; Xueyan Peng; Chuyan Tang; Ye Gan; Xiaosong Chen; Aditi Mathur; Buqu Hu; Martin D. Slade; Ruth R. Montgomery; Albert C. Shaw; Robert J. Homer; Eric S. White; Chang-Min Lee; Meagan W. Moore; Mridu Gulati; Chun Geun Lee; Jack A. Elias; Erica L. Herzog

doi:10.1126/scitranslmed.3007096

Research ArticleIdiopathic Pulmonary Fibrosis

Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

Yang Zhou¹,*,
Hong Peng²,*,
Huanxing Sun¹,*,
Xueyan Peng¹,
Chuyan Tang¹,
Ye Gan¹,
Xiaosong Chen¹,
Aditi Mathur¹,
Buqu Hu¹,
Martin D. Slade¹,
Ruth R. Montgomery³,
Albert C. Shaw³,
Robert J. Homer⁴,
Eric S. White⁵,
Chang-Min Lee¹,
Meagan W. Moore¹,
Mridu Gulati¹,
Chun Geun Lee¹,
Jack A. Elias⁶,† and
Erica L. Herzog¹,†

¹Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
²Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
³Program on Aging, Yale School of Medicine, New Haven, CT 06520, USA.
⁴Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
⁵Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
⁶Division of Biology and Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI 02912, USA.

↵†Corresponding author. E-mail: erica.herzog{at}yale.edu (E.L.H.); jack_elias{at}brown.edu (J.A.E.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 11 Jun 2014:
Vol. 6, Issue 240, pp. 240ra76
DOI: 10.1126/scitranslmed.3007096

Yang Zhou

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Hong Peng

Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.

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Huanxing Sun

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Xueyan Peng

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Chuyan Tang

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Ye Gan

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Xiaosong Chen

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Aditi Mathur

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Buqu Hu

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Martin D. Slade

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Ruth R. Montgomery

Program on Aging, Yale School of Medicine, New Haven, CT 06520, USA.

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Albert C. Shaw

Program on Aging, Yale School of Medicine, New Haven, CT 06520, USA.

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Robert J. Homer

Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.

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Eric S. White

Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

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Chang-Min Lee

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Meagan W. Moore

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Mridu Gulati

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Chun Geun Lee

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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Jack A. Elias

Division of Biology and Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI 02912, USA.

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For correspondence: erica.herzog@yale.edujack_elias@brown.edu

Erica L. Herzog

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

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For correspondence: erica.herzog@yale.edujack_elias@brown.edu

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Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

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