Contents

Contents

• Editorial

  • From Knowledge to Policy: Lessons from Africa

    By Juliet Nabyonga, Jackson Orem

    Science Translational Medicine11 Jun 2014 : 240ed13 Full AccessRestricted Access

    Partnerships that focus on the research and implementation of low-tech innovations can help to meet health care delivery challenges in low-income countries.

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• Perspective

  • RNAi Therapies: Drugging the Undruggable

    By Sherry Y. Wu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood

    Science Translational Medicine11 Jun 2014 : 240ps7 Full AccessRestricted Access

    New strategies are required to make RNA interference therapeutics a viable tool for cancer management.

    • Abstract
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• Research Articles

  • Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs

    By Elma Aflaki, Barbara K. Stubblefield, Emerson Maniwang, Grisel Lopez, Nima Moaven, Ehud Goldin, Juan Marugan, Samarjit Patnaik, Amalia Dutra, Noel Southall, Wei Zheng, Nahid Tayebi, Ellen Sidransky

    Science Translational Medicine11 Jun 2014 : 240ra73 Full AccessRestricted Access

    Macrophages differentiated from monocytes or induced pluripotent stem cells derived from patients with Gaucher disease facilitate investigation of disease pathogenesis and validation of new candidate drugs.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

    By Angeliki Asimaki, Sudhir Kapoor, Eva Plovie, Anne Karin Arndt, Edward Adams, ZhenZhen Liu, Cynthia A. James, Daniel P. Judge, Hugh Calkins, Jared Churko, Joseph C. Wu, Calum A. MacRae, André G. Kléber, Jeffrey E. Saffitz

    Science Translational Medicine11 Jun 2014 : 240ra74 Full AccessRestricted Access

    Drug screening in a zebrafish model of arrhythmogenic cardiomyopathy identified a small molecule that remodels the intercalated disc.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy

    By Jamey P. Weichert, Paul A. Clark, Irawati K. Kandela, Abram M. Vaccaro, William Clarke, Marc A. Longino, Anatoly N. Pinchuk, Mohammed Farhoud, Kyle I. Swanson, John M. Floberg, Joseph Grudzinski, Benjamin Titz, Anne M. Traynor, Hong-En Chen, Lance T. Hall, Christopher J. Pazoles, Perry J. Pickhardt, John S. Kuo

    Science Translational Medicine11 Jun 2014 : 240ra75 Full AccessRestricted Access

    Tumor-specific alkylphosphocholine analogs were evaluated as imaging and therapy agents in patients and in animal models of human cancer.

    • Editor's Summary
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    • Supplementary Materials

  • Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

    By Yang Zhou, Hong Peng, Huanxing Sun, Xueyan Peng, Chuyan Tang, Ye Gan, Xiaosong Chen, Aditi Mathur, Buqu Hu, Martin D. Slade, Ruth R. Montgomery, Albert C. Shaw, Robert J. Homer, Eric S. White, Chang-Min Lee, Meagan W. Moore, Mridu Gulati, Chun Geun Lee, Jack A. Elias, Erica L. Herzog

    Science Translational Medicine11 Jun 2014 : 240ra76 Full AccessRestricted Access

    Chitinase 3–like 1 protects against lung injury but has a profibrotic role during the repair phase.

    • Editor's Summary
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    • Supplementary Materials

• Editors' Choice

  • WANTED: Natural-Born Sickler

    By Mathieu Lemaire

    Science Translational Medicine11 Jun 2014 : 240ec101 Full AccessRestricted Access

    Sixty-five years after Pauling discovered the molecular basis of sickle cell anemia, the lipid S1P is found to be a critical player.

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  • Straight Shooters: Peptibodies Take Aim

    By Matthias Stephan

    Science Translational Medicine11 Jun 2014 : 240ec102 Full AccessRestricted Access

    Peptide antibodies (peptibodies) aim for and selectively deplete myeloid immune suppressor cells, leading to retarded tumor growth in mice.

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  • Antimicrobial Drug Resistance in All Four Corners of the Earth

    By Ephraim L. Tsalik

    Science Translational Medicine11 Jun 2014 : 240ec103 Full AccessRestricted Access

    Antibiotic resistance genes exist in multiple environmental and biological sources worldwide.

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• Podcast

  • Science Translational Medicine Podcast: 11 June 2014

    By John S. Kuo, Megan Frisk

    Science Translational Medicine11 Jun 2014 : 240pc2 Full AccessRestricted Access

    John S. Kuo describes a new class of small-molecule, cancer-selective imaging and therapeutic agents.

    • Abstract