Contents
Vol 6, Issue 240
Contents
Editorial
- From Knowledge to Policy: Lessons from Africa
Partnerships that focus on the research and implementation of low-tech innovations can help to meet health care delivery challenges in low-income countries.
Perspective
- RNAi Therapies: Drugging the Undruggable
New strategies are required to make RNA interference therapeutics a viable tool for cancer management.
Research Articles
- Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs
Macrophages differentiated from monocytes or induced pluripotent stem cells derived from patients with Gaucher disease facilitate investigation of disease pathogenesis and validation of new candidate drugs.
- Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy
Drug screening in a zebrafish model of arrhythmogenic cardiomyopathy identified a small molecule that remodels the intercalated disc.
- Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy
Tumor-specific alkylphosphocholine analogs were evaluated as imaging and therapy agents in patients and in animal models of human cancer.
- Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis
Chitinase 3–like 1 protects against lung injury but has a profibrotic role during the repair phase.
Editors' Choice
- WANTED: Natural-Born Sickler
Sixty-five years after Pauling discovered the molecular basis of sickle cell anemia, the lipid S1P is found to be a critical player.
- Straight Shooters: Peptibodies Take Aim
Peptide antibodies (peptibodies) aim for and selectively deplete myeloid immune suppressor cells, leading to retarded tumor growth in mice.
- Antimicrobial Drug Resistance in All Four Corners of the Earth
Antibiotic resistance genes exist in multiple environmental and biological sources worldwide.
Podcast
- Science Translational Medicine Podcast: 11 June 2014
John S. Kuo describes a new class of small-molecule, cancer-selective imaging and therapeutic agents.