Contents
Vol 6, Issue 239
Contents
Editorial
- Cardiovascular Genetics: Paying Individual Dividends
Recently identified genetic variations that underlie cardiovascular disease are changing clinical practice.
Focus
- Endothelial Insights: The Florian Dialectic
In heart healing, engineering technology has driven translation by bridging biology and medicine.
Perspectives
- Atherosclerosis—Multiple Pathways to Lesional Macrophages
The origin and molecular regulation of macrophages may shape the development of effective treatments for atherosclerosis.
- MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease
MicroRNAs play central roles in cardiovascular disease, and their therapeutic manipulation raises exciting opportunities as well as challenges in the path toward clinical development.
- New Therapies for Coronary Artery Disease: Genetics Provides a Blueprint
Human genetics has the potential to identify future targets for successful therapeutic interventions for cardiovascular disease.
- Common Therapeutic Targets in Cardiometabolic Disease
Cardiovascular disease and insulin resistance syndrome interactions provide joint therapeutic targets.
- Human Stem Cells for Modeling Heart Disease and for Drug Discovery
This Perspective highlights recent research progress in the use of stem cells and progenitor cells for disease modeling, drug discovery, and cardiac regeneration.
State of the Art Review
- Imaging and Nanomedicine in Inflammatory Atherosclerosis
The integration of immunology and cardiovascular medicine with engineering and nanotechnology will yield precision diagnostics and efficient therapeutics for atherosclerosis and its ischemic complications.
Review
- Strategies for Cardiac Regeneration and Repair
Regenerative medicine strategies that enhance heart repair are being pursued to face the growing heart disease epidemic.
Editors' Choice
- Metabolic Syndrome: A Family Affair
A rare genetic mutation found to cause human metabolic syndrome may shed light on more common forms of cardiometabolic disease.
- Vaping—Vaccine or Virus?
Despite the growing popularity of electronic cigarettes, little is known about whether these nicotine-delivery devices hinder or help smokers in their efforts to quit.
- Removing the Veil from Cancer Stem Cells
The evaluation of human patient specimens provides in vivo evidence that cancer stem cells drive myelodysplastic syndromes.
- “Brain-Critical” Exons in Autism
Select brain-expressed exons may be targets for disease-causing mutations in autism.
- Genetic Polymorphisms Spill Their Guts
Dendritic cells isolated from patients with ICOSLG polymorphisms are unable to secrete appropriate levels of inflammatory cytokines, leading to increased disease.
