21 May 2014
Vol 6, Issue 237
  • Contents

    • Focus

      • A Stiffness-Mediated Oncogenic Hammer

        A recent study in Nature Medicine identified a tissue stiffness–induced microRNA that mediates oncogenic signaling; interestingly, its expression stratifies luminal breast cancer survivors to predict accelerated metastatic relapse.

      • Many Fences Make Better Neighbors

        Phagocytic Kupffer cells in the liver act as a firewall that captures commensal bacteria that have breached the barrier of the gut mucosa (Balmer et al., this issue).

    • Research Articles

    • Editors' Choice

      • SNFing Out Vulnerability in Cancer

        SWI/SWF proteins, including ARID1A and ARID1B, are required for cellular resistance to DNA damage.

      • Losing Brain

        A study of college football players shows that more years of active play are associated with smaller volumes of the hippocampus, a brain region underlying cognition and learning.

      • How Does the Heart Heal?

        Long noncoding RNAs predict patterns of adverse healing after myocardial infarction in a mouse model.

About The Cover

Cover image expansion

ONLINE COVER A Roadblock for Supressive Immune Cells. Tumors are not static structures, but dynamic microenvironments. Immune cell trafficking into a tumor is critical for successful immunotherapy; however, tumors can alter immune function, in part by recruiting immune cells—such as myeloid-derived suppressor cells (MDSCs)—that block antitumor immune responses. Now, Highfill et al. show in a mouse model of rhabdomyosarcoma that blocking MDSC trafficking to the tumor through CXCR2, in conjunction with the checkpoint blockade anti-PD1, may help prevent tumor escape. [CREDIT: GETTY IMAGES/iSTOCKPHOTO]