21 May 2014
Vol 6, Issue 237

About The Cover

Cover image expansion

ONLINE COVER A Roadblock for Supressive Immune Cells. Tumors are not static structures, but dynamic microenvironments. Immune cell trafficking into a tumor is critical for successful immunotherapy; however, tumors can alter immune function, in part by recruiting immune cells—such as myeloid-derived suppressor cells (MDSCs)—that block antitumor immune responses. Now, Highfill et al. show in a mouse model of rhabdomyosarcoma that blocking MDSC trafficking to the tumor through CXCR2, in conjunction with the checkpoint blockade anti-PD1, may help prevent tumor escape. [CREDIT: GETTY IMAGES/iSTOCKPHOTO]