Research ArticleHIV

Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

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Science Translational Medicine  14 May 2014:
Vol. 6, Issue 236, pp. 236ra63
DOI: 10.1126/scitranslmed.3008104

Article Information

vol. 6 no. 236 236ra63

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 21, 2013
  • Accepted for publication March 21, 2014
  • .

Author Information

  1. Devin Sok1,2,3,*,
  2. Katie J. Doores1,2,3,4,*,,
  3. Bryan Briney1,2,3,
  4. Khoa M. Le1,2,3,
  5. Karen L. Saye-Francisco1,2,3,
  6. Alejandra Ramos1,2,3,5,
  7. Daniel W. Kulp1,2,3,5,
  8. Jean-Philippe Julien2,3,6,
  9. Sergey Menis1,2,3,5,
  10. Lalinda Wickramasinghe1,2,3,5,
  11. Michael S. Seaman7,
  12. William R. Schief1,2,3,5,8,
  13. Ian A. Wilson2,3,6,9,
  14. Pascal Poignard1,2,5 and
  15. Dennis R. Burton1,2,3,8,
  1. 1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  2. 2International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  3. 3Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
  4. 4Department of Infectious Diseases, King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK.
  5. 5International AIDS Vaccine Initiative, New York, NY 10038, USA.
  6. 6Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  7. 7Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  8. 8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, MA 02142, USA.
  9. 9Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  1. Corresponding author. E-mail: burton{at}scripps.edu (D.R.B.); katie.doores{at}kcl.ac.uk (K.J.D.)
  • * These authors contributed equally to this work.

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