Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

Tatiana Perova; Ildiko Grandal; Lauryl M. J. Nutter; Eniko Papp; Irina R. Matei; Joseph Beyene; Paul E. Kowalski; Johann K. Hitzler; Mark D. Minden; Cynthia J. Guidos; Jayne S. Danska

doi:10.1126/scitranslmed.3008661

Research ArticleLeukemia

Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

Tatiana Perova¹,²,
Ildiko Grandal¹,
Lauryl M. J. Nutter¹,
Eniko Papp¹,²,
Irina R. Matei¹,²,
Joseph Beyene³,
Paul E. Kowalski¹,
Johann K. Hitzler¹,⁴,
Mark D. Minden²,⁵,
Cynthia J. Guidos¹,⁶ and
Jayne S. Danska²,⁷,*

¹Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
²Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
³Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
⁴Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
⁵Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario M5T 2M9, Canada.
⁶Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
⁷Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

↵*Corresponding author. E-mail: jayne.danska{at}sickkids.ca

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Science Translational Medicine 14 May 2014:
Vol. 6, Issue 236, pp. 236ra62
DOI: 10.1126/scitranslmed.3008661

Tatiana Perova

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

2Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Ildiko Grandal

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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Lauryl M. J. Nutter

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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Eniko Papp

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

2Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Irina R. Matei

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

2Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Joseph Beyene

3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8S 4L8, Canada.

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Paul E. Kowalski

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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Johann K. Hitzler

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

4Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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Mark D. Minden

2Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

5Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario M5T 2M9, Canada.

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Cynthia J. Guidos

1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

6Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Jayne S. Danska

2Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

7Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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For correspondence: jayne.danska@sickkids.ca

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Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

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