07 May 2014
Vol 6, Issue 235

About The Cover

Cover image expansion

ONLINE COVER The Architecture of a Vaccine Adjuvant. Sometimes the whole is greater than the sum of the parts. CpG oligodeoxynucleotides (ODNs) are short single-stranded synthetic DNA molecules that activate the immune system. However, ODNs with different structures induce different immunological responses. In this week's issue of Science Translational Medicine, Gungor and colleagues describe a nanoring made of ODNs that enhance immune function and may serve as a vaccine adjuvant. [CREDIT: TOMOGRAF/ISTOCKPHOTO]