Contents
Vol 6, Issue 234
Contents
Focus
- Using Humans to Make a Human Leishmaniasis Vaccine
The cellular immune response to peptide pools from conserved Leishmania antigens in leishmaniasis-immune individuals identified epitopes for a human DNA vaccine (Das et al., this issue).
Commentary
- Biobanks and Electronic Medical Records: Enabling Cost-Effective Research
Linking of data from electronic medical records to biological specimens enables cost-effective and rapid genomic analyses.
Research Articles
- A Cell Culture–Derived MF59-Adjuvanted Pandemic A/H7N9 Vaccine Is Immunogenic in Adults
An MF59-adjuvanted A/H7N9 candidate vaccine shows promise in the face of a possible A/H7N9 pandemic.
- Modular Multiantigen T Cell Epitope–Enriched DNA Vaccine Against Human Leishmaniasis
A DNA vaccine for the induction of cell-mediated immunity against different types of leishmaniasis was developed and successfully tested in human cell culture systems for immunogenicity and an animal model for prophylaxis.
- Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records
Twenty-six traits were associated with diseases through similarities in genetic variation and validated from electronic medical records.
- An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss
Scaffolds composed of cell-free extracellular matrix promote de novo formation of functional skeletal muscle tissue in sites of volumetric muscle loss.
- Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein
Human neutralizing monoclonal antibody could serve as a therapeutic intervention against MERS-CoV infection.
Editors' Choice
- SYMPLICITY—Not as Simple as One, Two, Three
Extensive pre- and early clinical evidence indicated that renal sympathetic denervation effectively treats hypertension, yet the well-controlled SYMPLICITY HTN-3 trial failed.
- PGE2—The Immune System Tamer
By chelating bioactive PGE2, a molecule with immunosuppressive properties, albumin helps preserve normal immune function.
- An “Exciting” Way to Heal
Enhancing depression-causing hyperexcitability in dopamine neurons alleviates depression-like behavior in mice.
- Carbon Nanotubes Are Picky Hitchhikers
A new class of nanoparticles are taken up by a subset of monocytes in vivo for imaging and therapy of cancer, cardiovascular disease, and certain autoimmune diseases.
- The Sum of One’s Parts? What Our Microbiomes Say About Us
The human microbiome, as defined by microbial community types, reflects our experiences in ways that depend on anatomic location.
