Research ArticleCROHN’S DISEASE

Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn’s Disease

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Science Translational Medicine  23 Apr 2014:
Vol. 6, Issue 233, pp. 233ra53
DOI: 10.1126/scitranslmed.3006763

Article Information

vol. 6 no. 233 233ra53

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 10, 2013
  • Accepted for publication March 4, 2014
  • .

Author Information

  1. Kaushal Parikh1,2,3,4,*,
  2. Lu Zhou1,5,6,*,
  3. Rajesh Somasundaram4,*,
  4. Gwenny M. Fuhler4,*,
  5. J. Jasper Deuring4,
  6. Tjasso Blokzijl7,
  7. Anouk Regeling6,
  8. Ernst J. Kuipers4,
  9. Rinse K. Weersma6,
  10. Veerle J. Nuij4,
  11. Maria Alves4,
  12. Lauran Vogelaar4,
  13. Lydia Visser8,
  14. Colin de Haar4,
  15. Kausilia K. Krishnadath3,
  16. C. Janneke van der Woude4,
  17. Gerard Dijkstra6,,
  18. Klaas Nico Faber6, and
  19. Maikel P. Peppelenbosch1,4,
  1. 1Department of Cell Biology, University Medical Center Groningen, University of Groningen, Deusinglaan 1, NL-9713 AV Groningen, the Netherlands.
  2. 2Centre for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, NL-1105 AZ Amsterdam, the Netherlands.
  3. 3Department of Gastroenterology and Hepatology, Academic Medical Center, NL-1105AZ Amsterdam, the Netherlands.
  4. 4Department of Gastroenterology and Hepatology, Erasmus MC, P. O. Box 2040, NL-3000 CA Rotterdam, the Netherlands.
  5. 5Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300060, People’s Republic of China.
  6. 6Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, NL-9713 AV Groningen, the Netherlands.
  7. 7Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, NL-9713 AV Groningen, the Netherlands.
  8. 8Department of Pathology, University Medical Center Groningen, University of Groningen, NL-9713 AV Groningen, the Netherlands.
  1. Corresponding author. E-mail: m.peppelenbosch{at}erasmusmc.nl
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

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