Research ArticleCROHN’S DISEASE

Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn’s Disease

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Science Translational Medicine  23 Apr 2014:
Vol. 6, Issue 233, pp. 233ra53
DOI: 10.1126/scitranslmed.3006763

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Crohn’s Disease on the Rac

Crohn’s disease is a type of inflammatory bowel disease (IBD), wherein the body’s immune system attacks the gastrointestinal tract. In patients with Crohn’s, there are areas of apparently healthy tissue right next to damaged intestine, but it remains unclear what differentiates healthy and inflamed regions. Now, Parikh et al. examine signal transduction differences in healthy and inflamed tissue to find targets that may be protective in Crohn’s.

The authors performed a comparative kinome profile in healthy controls as well as healthy and inflamed tissues from Crohn’s patients. They found that p21Rac1 GTPase signaling is suppressed in noninflamed tissue. What’s more, blocking p21Rac1 correlated with clinical improvement of IBD, potentially by boosting innate immune responses. These data suggest that blocking p21Rac1 may be protective for IBD.

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