Contents

Contents

• Editorial

  • Educational Games for Malaria Diagnosis

    By Aydogan Ozcan

    Science Translational Medicine23 Apr 2014 : 233ed9 Full AccessRestricted Access

    On World Malaria Day, BioGames will release its malaria cell image library to the public as an educational training module and expert scoring system.

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• Focus

  • Gene Therapy Boosts the Bionic Ear

    By Robert K. Shepherd, Andrew K. Wise

    Science Translational Medicine23 Apr 2014 : 233fs17 Full AccessRestricted Access

    Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear (Pinyon et al., this issue).

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• Research Articles

  • Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn’s Disease

    By Kaushal Parikh, Lu Zhou, Rajesh Somasundaram, Gwenny M. Fuhler, J. Jasper Deuring, Tjasso Blokzijl, Anouk Regeling, Ernst J. Kuipers, Rinse K. Weersma, Veerle J. Nuij, Maria Alves, Lauran Vogelaar, Lydia Visser, Colin de Haar, Kausilia K. Krishnadath, C. Janneke van der Woude, Gerard Dijkstra, Klaas Nico Faber, Maikel P. Peppelenbosch

    Science Translational Medicine23 Apr 2014 : 233ra53 Full AccessRestricted Access

    Overactivation of p21Rac1 is a rate-limiting step for innate immune function in Crohn’s disease and prevents remission.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

    By Jeremy L. Pinyon, Sherif F. Tadros, Kristina E. Froud, Ann C. Y. Wong, Isabella T. Tompson, Edward N. Crawford, Myungseo Ko, Renée Morris, Matthias Klugmann, Gary D. Housley

    Science Translational Medicine23 Apr 2014 : 233ra54 Full AccessRestricted Access

    Neurotrophin gene delivery, achieved by “close-field” electroporation of mesenchymal cells adjacent to the cochlear implant, improved hearing in deafened guinea pigs.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

• Reports

  • Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (HPGD)

    By Stephen P. Fink, Mai Yamauchi, Reiko Nishihara, Seungyoun Jung, Aya Kuchiba, Kana Wu, Eunyoung Cho, Edward Giovannucci, Charles S. Fuchs, Shuji Ogino, Sanford D. Markowitz, Andrew T. Chan

    Science Translational Medicine23 Apr 2014 : 233re2 Full AccessRestricted Access

    Aspirin use is associated with a lower risk of colorectal cancer arising in association with high expression of 15-PGDH (HPGD) in normal colon mucosa.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

• Editors' Choice

  • A Pregnant Pause in Pancreatic Function

    By Saptarsi M. Haldar

    Science Translational Medicine23 Apr 2014 : 233ec70 Full AccessRestricted Access

    The furan fatty acid metabolite CMPF might drive pathogenesis of gestational and type 2 diabetes in humans.

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  • A Chink in Glioblastoma’s Armor

    By Justin D. Lathia

    Science Translational Medicine23 Apr 2014 : 233ec71 Full AccessRestricted Access

    Inducing vacuole formation with a quinolone alcohol–based drug stimulates cell death in glioblastoma cells.

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  • SNFing for Clues to the Genetics of Autism

    By Heather C. Mefford

    Science Translational Medicine23 Apr 2014 : 233ec72 Full AccessRestricted Access

    Mutations in the ADNP gene, which encodes a component of a nucleosome remodeling complex, play a role in some cases of autism spectrum disorder.

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  • Putting the Brakes on Inflammation to Control Sepsis

    By June L. Round

    Science Translational Medicine23 Apr 2014 : 233ec73 Full AccessRestricted Access

    During sepsis, VEGF-C is induced by blood-borne bacterial products and binds to its receptor, down-regulating inflammation.

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• Erratum

  • Erratum for the Research Article: “Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction” by S. B. Seif-Naraghi, J. M. Singelyn, M. A. Salvatore, K. G. Osborn, J. J. Wang, U. Sampat, O. L. Kwan, G. M. Strachan, J. Wong, P. J. Schup-Magoffin, R. L. Braden, K. Bartels, J. A. DeQuach, M. Preul, A. M. Kinsey, A. N. DeMaria, N. Dib, K. L. Christman

    Science Translational Medicine23 Apr 2014 : 233er2 Full AccessRestricted Access

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