Contents
Vol 6, Issue 233
Contents
Editorial
- Educational Games for Malaria Diagnosis
On World Malaria Day, BioGames will release its malaria cell image library to the public as an educational training module and expert scoring system.
Focus
- Gene Therapy Boosts the Bionic Ear
Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear (Pinyon et al., this issue).
Research Articles
- Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn’s Disease
Overactivation of p21Rac1 is a rate-limiting step for innate immune function in Crohn’s disease and prevents remission.
- Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear
Neurotrophin gene delivery, achieved by “close-field” electroporation of mesenchymal cells adjacent to the cochlear implant, improved hearing in deafened guinea pigs.
Reports
- Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (HPGD)
Aspirin use is associated with a lower risk of colorectal cancer arising in association with high expression of 15-PGDH (HPGD) in normal colon mucosa.
Editors' Choice
- A Pregnant Pause in Pancreatic Function
The furan fatty acid metabolite CMPF might drive pathogenesis of gestational and type 2 diabetes in humans.
- A Chink in Glioblastoma’s Armor
Inducing vacuole formation with a quinolone alcohol–based drug stimulates cell death in glioblastoma cells.
- SNFing for Clues to the Genetics of Autism
Mutations in the ADNP gene, which encodes a component of a nucleosome remodeling complex, play a role in some cases of autism spectrum disorder.
- Putting the Brakes on Inflammation to Control Sepsis
During sepsis, VEGF-C is induced by blood-borne bacterial products and binds to its receptor, down-regulating inflammation.
Erratum